Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1954938..1955665 Replicon chromosome
Accession NZ_CP019706
Organism Pantoea alhagi strain LTYR-11Z

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B1H58_RS09175 Protein ID WP_085069630.1
Coordinates 1955354..1955665 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B1H58_RS09170 Protein ID WP_085069629.1
Coordinates 1954938..1955357 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1H58_RS09145 1950796..1952112 + 1317 WP_085069622.1 maltoporin -
B1H58_RS09150 1952208..1953161 + 954 WP_085069624.1 maltose operon protein MalM -
B1H58_RS20595 1953437..1953745 - 309 WP_157130160.1 hypothetical protein -
B1H58_RS09165 1954271..1954804 - 534 WP_085069627.1 hypothetical protein -
B1H58_RS09170 1954938..1955357 - 420 WP_085069629.1 helix-turn-helix domain-containing protein Antitoxin
B1H58_RS09175 1955354..1955665 - 312 WP_085069630.1 type II toxin-antitoxin system HigB family toxin Toxin
B1H58_RS20600 1955785..1956036 - 252 WP_157130161.1 hypothetical protein -
B1H58_RS09185 1956450..1956977 + 528 WP_085069635.1 chorismate lyase -
B1H58_RS09190 1956979..1957860 + 882 WP_085072271.1 4-hydroxybenzoate octaprenyltransferase -
B1H58_RS09195 1957948..1960371 - 2424 WP_085069637.1 glycerol-3-phosphate 1-O-acyltransferase PlsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12240.93 Da        Isoelectric Point: 9.9445

>T73205 WP_085069630.1 NZ_CP019706:c1955665-1955354 [Pantoea alhagi]
MHVISKEPFEQAARSFPNDATAIKALYRLVRETNFKTPDELRAAVPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKLF
YVKHNATHAEYDKLTRYYRENKE

Download         Length: 312 bp

>T73205 NZ_CP019706:c1955665-1955354 [Pantoea alhagi]
ATGCACGTCATTTCAAAAGAGCCATTTGAGCAAGCGGCGCGGTCATTTCCTAACGATGCCACGGCCATCAAGGCGCTGTA
TCGTCTGGTACGCGAAACAAACTTCAAAACGCCCGATGAACTGCGCGCCGCCGTGCCAAGCCTGGACAATTTTAAGTACC
GTAACAAATGGTGGGTTTTAGATGTAGGGGGCAACAATTTGCGAGTAATCGCCTACATCAACTTCGTGAATAAGCTCTTC
TACGTGAAGCACAACGCCACCCACGCTGAATACGATAAGCTGACTCGCTACTATCGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15407.58 Da        Isoelectric Point: 4.7729

>AT73205 WP_085069629.1 NZ_CP019706:c1955357-1954938 [Pantoea alhagi]
MIADTTKAIEATKLLVAAVPLLGGSTSEKDYRDALALVDYLIDHDDENPLLDFLAAKIADYEDNSERFAEFNKEVAEMPV
GVALLRTLIDQHKLSYSDLKNEIGSKSLVSQILSGQRSLTISHIKALSNRFGVKPQWFL

Download         Length: 420 bp

>AT73205 NZ_CP019706:c1955357-1954938 [Pantoea alhagi]
ATGATCGCCGACACCACTAAAGCTATCGAAGCAACGAAACTACTGGTAGCTGCCGTCCCCCTGCTGGGGGGCAGCACCTC
AGAGAAAGACTACCGTGACGCGCTGGCGCTGGTGGACTACCTGATTGACCACGACGACGAAAACCCGCTGCTCGACTTCC
TGGCGGCCAAAATCGCCGATTATGAAGACAACAGCGAACGCTTTGCGGAGTTCAACAAAGAAGTCGCAGAAATGCCGGTG
GGCGTTGCGCTGCTGCGCACGCTGATTGACCAGCATAAGCTGTCCTACTCCGACCTGAAGAATGAGATCGGCTCAAAATC
GCTGGTGAGCCAAATCCTCTCCGGCCAGCGCTCCCTGACGATCTCACACATCAAGGCGCTTTCGAACCGGTTCGGCGTGA
AGCCTCAATGGTTCCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References