Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 166185..166909 Replicon chromosome
Accession NZ_CP019706
Organism Pantoea alhagi strain LTYR-11Z

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B1H58_RS00700 Protein ID WP_085067513.1
Coordinates 166185..166496 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B1H58_RS00705 Protein ID WP_085067514.1
Coordinates 166493..166909 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1H58_RS00685 161824..164265 - 2442 WP_085067510.1 mechanosensitive ion channel family protein -
B1H58_RS00690 164454..164996 + 543 WP_085067511.1 GNAT family N-acetyltransferase -
B1H58_RS00695 165001..165936 - 936 WP_085067512.1 D-alanyl-D-alanine endopeptidase -
B1H58_RS00700 166185..166496 + 312 WP_085067513.1 type II toxin-antitoxin system HigB family toxin Toxin
B1H58_RS00705 166493..166909 + 417 WP_085067514.1 helix-turn-helix domain-containing protein Antitoxin
B1H58_RS00710 166995..167582 - 588 WP_085067515.1 YIP1 family protein -
B1H58_RS00715 167760..168335 + 576 WP_085067516.1 DedA family protein -
B1H58_RS00720 168332..169093 - 762 WP_085067517.1 iron export ABC transporter permease subunit FetB -
B1H58_RS00725 169090..169743 - 654 WP_085067518.1 ATP-binding cassette domain-containing protein -
B1H58_RS00730 169852..170637 - 786 WP_085067519.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12503.37 Da        Isoelectric Point: 9.9932

>T73199 WP_085067513.1 NZ_CP019706:166185-166496 [Pantoea alhagi]
MHIITREPFDKAAKRFPNHALALDDLYRHLKRVRFTSPEDLNETFPSLDRMKYREKWWVIDIGGGNLRVMFFADFERGKI
FIKHIATHAEYDKLTDFYRRNKE

Download         Length: 312 bp

>T73199 NZ_CP019706:166185-166496 [Pantoea alhagi]
ATGCATATTATTACGAGGGAACCCTTCGATAAAGCTGCAAAGCGTTTTCCCAACCATGCTTTAGCGCTTGATGACTTATA
TCGCCACTTAAAGCGGGTAAGGTTTACCAGCCCGGAAGATCTTAATGAAACCTTCCCCAGCCTGGACAGAATGAAGTATC
GCGAAAAATGGTGGGTAATCGATATAGGAGGCGGCAATCTGCGCGTCATGTTCTTTGCAGATTTTGAGCGAGGGAAGATC
TTTATAAAGCATATAGCCACTCACGCAGAATACGATAAGTTGACTGACTTTTATCGGAGAAACAAAGAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15749.06 Da        Isoelectric Point: 5.0126

>AT73199 WP_085067514.1 NZ_CP019706:166493-166909 [Pantoea alhagi]
MIFSDAIEAADSLVRILPLLGGSTCRKDYEEAVRLVEYLVEHQPDSPLIEMLTAKIDAYENNAPEFAEFNARIDTEPHGV
SLLRILMDQYGLNQTDFAKEIGQRSLVSRILKGERKLTLEHMRNLAKRFNIPVSRFVD

Download         Length: 417 bp

>AT73199 NZ_CP019706:166493-166909 [Pantoea alhagi]
ATGATTTTCAGCGACGCAATTGAGGCAGCAGATAGCCTGGTGAGAATTCTCCCTCTGTTAGGAGGCAGCACTTGCCGTAA
AGACTATGAAGAAGCGGTCAGGCTGGTGGAATATCTGGTGGAGCATCAGCCAGACAGCCCGCTGATCGAAATGCTGACAG
CGAAAATTGATGCTTATGAAAACAATGCACCAGAATTTGCCGAGTTTAATGCACGTATTGATACCGAACCGCATGGCGTA
TCATTGTTACGTATTTTGATGGATCAATATGGACTTAATCAAACCGACTTTGCAAAAGAGATTGGTCAGCGTTCGCTGGT
AAGCCGCATATTAAAAGGTGAACGTAAGCTGACGCTGGAACATATGCGTAACCTGGCTAAACGCTTTAACATCCCGGTAA
GCCGCTTCGTCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References