Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4368978..4369617 Replicon chromosome
Accession NZ_CP019689
Organism Shigella sonnei strain 75/02

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BZ172_RS23845 Protein ID WP_225380621.1
Coordinates 4369276..4369617 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BZ172_RS23840 Protein ID WP_047199903.1
Coordinates 4368978..4369286 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ172_RS23800 (4364345) 4364345..4364641 + 297 WP_000084292.1 CII family transcriptional regulator -
BZ172_RS23805 (4364656) 4364656..4364874 + 219 WP_000438870.1 hypothetical protein -
BZ172_RS23810 (4364895) 4364895..4365983 + 1089 WP_094112554.1 DNA-binding protein -
BZ172_RS23815 (4365990) 4365990..4366730 + 741 WP_000790395.1 ATP-binding protein -
BZ172_RS23820 (4366756) 4366756..4367526 + 771 WP_000450880.1 DUF1627 domain-containing protein -
BZ172_RS23825 (4367541) 4367541..4367972 + 432 WP_001151119.1 DUF977 family protein -
BZ172_RS23830 (4368005) 4368005..4368679 - 675 WP_000060692.1 DUF4145 domain-containing protein -
BZ172_RS23835 (4368678) 4368678..4368923 + 246 WP_000354190.1 hypothetical protein -
BZ172_RS23840 (4368978) 4368978..4369286 - 309 WP_047199903.1 helix-turn-helix transcriptional regulator Antitoxin
BZ172_RS23845 (4369276) 4369276..4369617 - 342 WP_225380621.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BZ172_RS23850 (4369783) 4369783..4370259 + 477 WP_238584173.1 hypothetical protein -
BZ172_RS23855 (4370271) 4370271..4370942 + 672 WP_001624511.1 hypothetical protein -
BZ172_RS23860 (4370962) 4370962..4371336 - 375 WP_001624512.1 DUF805 domain-containing protein -
BZ172_RS23865 (4371681) 4371681..4372349 + 669 WP_047199905.1 ORF6N domain-containing protein -
BZ172_RS23870 (4372404) 4372404..4372814 + 411 WP_047199906.1 recombination protein NinB -
BZ172_RS23875 (4372811) 4372811..4373002 + 192 WP_001254268.1 NinE family protein -
BZ172_RS23880 (4373026) 4373026..4373316 + 291 WP_050866488.1 DUF1364 domain-containing protein -
BZ172_RS23885 (4373313) 4373313..4373675 + 363 WP_050866487.1 RusA family crossover junction endodeoxyribonuclease -
BZ172_RS23890 (4373675) 4373675..4373869 + 195 WP_000992060.1 protein ninH -
BZ172_RS23895 (4373862) 4373862..4374242 + 381 WP_001204861.1 antiterminator Q family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - stxA / stxB 4354680..4428424 73744


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(20-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13290.56 Da        Isoelectric Point: 9.9761

>T73192 WP_225380621.1 NZ_CP019689:c4369617-4369276 [Shigella sonnei]
MLIPMNYTIEYYSEEVRLEVDQLPLSMRVRYKHLIERMKVYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKR
IIMLHSFIKKTQKTPPAERKKAEARMKEVKHDW

Download         Length: 342 bp

>T73192 NZ_CP019689:c4369617-4369276 [Shigella sonnei]
ATGTTGATACCTATGAACTACACTATCGAATACTACAGTGAAGAGGTCCGGCTGGAAGTCGATCAGCTTCCATTGAGTAT
GCGTGTCCGATACAAACATCTCATTGAACGTATGAAGGTATACGGCAGCAATCTCGGAGAACCTCATACCAGCGCCTTTG
GTGATGGGCTTTTCGAACTCAGAATTAAAGGCAACGATGGGATTGCACGTGTTTTTTACTGCACTCTGACAGGGAAACGC
ATCATTATGCTGCATAGTTTCATTAAGAAAACGCAGAAAACACCGCCAGCCGAACGCAAAAAAGCTGAAGCCAGAATGAA
GGAGGTTAAGCATGACTGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11185.94 Da        Isoelectric Point: 8.5840

>AT73192 WP_047199903.1 NZ_CP019689:c4369286-4368978 [Shigella sonnei]
MTGKRITPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISG
PSFATLKKFARATGKKLQIRFV

Download         Length: 309 bp

>AT73192 NZ_CP019689:c4369286-4368978 [Shigella sonnei]
ATGACTGGTAAACGCATTACACCTACCATGACACACGACGAAATGGCAGCCAAATGGATGGAGGATCCGGCTTTCAAAGC
AGAATACGACGCCATCGCCGACGAATTCGCACTACTTGATGAAATGCTGGCAGCACGAAAAGAAGCAGGCTTAACCCAGG
CTGAAGTTGCTGAACGTATGGGAACAAAAGCGACTGCGATCACCAGAATGGAAAGCAATCTTGCATCAGGTATAAGCGGC
CCATCATTTGCCACACTGAAAAAATTCGCCCGTGCTACAGGGAAAAAACTCCAGATCCGCTTCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References