Detailed information of TA system TA073166

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 3158841..3159678
• Replicon: chromosome
• Accession: NZ_CP019686
• Organism: Proteus sp. CD3

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: BTA34_RS14135
• Protein ID: WP_151436113.1
• Coordinates: 3159184..3159678 (+)
• Length: 165 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: BTA34_RS14130
• Protein ID: WP_151436112.1
• Coordinates: 3158841..3159173 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTA34_RS14120 (BTA34_14140)	3155344..3156783	-	1440	WP_151436111.1	alkaline phosphatase	-
BTA34_RS14125 (BTA34_14145)	3157027..3158583	-	1557	WP_265576097.1	alpha/beta hydrolase-fold protein	-
BTA34_RS14130 (BTA34_14150)	3158841..3159173	+	333	WP_151436112.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
BTA34_RS14135 (BTA34_14155)	3159184..3159678	+	495	WP_151436113.1	type II toxin-antitoxin system YhaV family toxin	Toxin
BTA34_RS14140 (BTA34_14160)	3159777..3160916	-	1140	WP_151436114.1	ElyC/SanA/YdcF family protein	-
BTA34_RS14145 (BTA34_14165)	3161299..3162543	-	1245	WP_151436115.1	multifunctional transcriptional regulator/nicotinamide-nucleotide adenylyltransferase/ribosylnicotinamide kinase NadR	-
BTA34_RS14150 (BTA34_14170)	3162555..3163946	-	1392	WP_151436116.1	DNA repair protein RadA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (11-147)

Antitoxin

• PrlF antitoxin (13-110)

Sequences

Toxin

Protein

• Length: 165 a.a.
• Molecular weight: 18977.86 Da
• Isoelectric Point: 10.0167

>T73166 WP_151436113.1 NZ_CP019686:3159184-3159678 [Proteus sp. CD3]
MDTLEINGWKIFFHQCFLDQIIELIENVKKLKASDPSGYKKKNATKLLTAIKKVIEERIARNPLDPIFHLGNTLGSNNKH
WFRAKFLQQFRLFFRCSEEHKIIVIGWVNDFNTLRAYDSKSDAYKVFSSKLKAGKPPNDWQTLLKEASATAGAETLSIQD
FFNH

Nucleotide

• Length: 495 bp

>T73166 NZ_CP019686:3159184-3159678 [Proteus sp. CD3]
ATGGATACTTTAGAAATTAACGGCTGGAAAATCTTTTTTCACCAATGCTTTTTGGATCAGATTATTGAATTGATCGAAAA
CGTCAAAAAATTGAAAGCATCAGATCCAAGTGGGTATAAGAAAAAAAACGCCACTAAACTACTTACAGCAATCAAAAAAG
TAATAGAAGAACGTATAGCTAGAAATCCGCTCGATCCTATATTTCATCTAGGAAACACATTAGGATCTAATAATAAACAT
TGGTTTAGAGCGAAGTTCTTACAACAGTTTCGTTTATTTTTTCGATGCAGTGAAGAACATAAGATCATCGTTATTGGTTG
GGTTAATGATTTTAATACACTACGTGCTTACGACTCTAAAAGTGATGCATATAAAGTATTTTCATCAAAACTAAAAGCAG
GAAAGCCACCAAATGATTGGCAAACATTGCTAAAAGAAGCTTCTGCCACAGCAGGAGCAGAAACGCTCTCAATTCAAGAT
TTTTTCAATCACTAG

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12399.15 Da
• Isoelectric Point: 4.3332

>AT73166 WP_151436112.1 NZ_CP019686:3158841-3159173 [Proteus sp. CD3]
MILNIEDVSLRAESRLTERSQTTIPAAIRDALQLKPGELIEYSLLPGGRVIISRQEKEQDDPVISEFLSFLEKDMKKNPQ
HIKSVPTTLWAEVKELTDGVEIDLDAPLTD

Nucleotide

• Length: 333 bp

>AT73166 NZ_CP019686:3158841-3159173 [Proteus sp. CD3]
ATGATCCTAAATATTGAGGATGTGTCTCTACGCGCTGAATCTCGACTCACTGAGCGTAGTCAAACAACAATTCCTGCGGC
CATTCGGGATGCTTTACAGCTAAAGCCGGGAGAATTAATTGAATATTCTCTATTACCTGGGGGTAGAGTCATTATATCTC
GACAAGAAAAGGAACAAGATGATCCCGTTATATCTGAATTTCTCTCTTTCCTTGAAAAAGATATGAAGAAAAACCCACAG
CATATCAAATCAGTACCTACAACATTATGGGCTGAGGTGAAAGAGCTTACTGATGGCGTTGAAATTGACTTAGACGCACC
ACTTACTGACTAG