Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 223940..224597 Replicon chromosome
Accession NZ_CP019672
Organism Burkholderia cenocepacia strain VC12308

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A8E75_RS01125 Protein ID WP_077189898.1
Coordinates 223940..224272 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A8E75_RS01130 Protein ID WP_077189769.1
Coordinates 224265..224597 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8E75_RS01100 219146..220720 - 1575 WP_077189899.1 hypothetical protein -
A8E75_RS01110 221067..221381 + 315 WP_006494471.1 hypothetical protein -
A8E75_RS01115 221375..222184 + 810 WP_077189771.1 glycosyltransferase family 25 protein -
A8E75_RS01120 222718..223560 + 843 WP_077189770.1 peptidyl-prolyl cis-trans isomerase -
A8E75_RS01125 223940..224272 + 333 WP_077189898.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8E75_RS01130 224265..224597 + 333 WP_077189769.1 helix-turn-helix domain-containing protein Antitoxin
A8E75_RS01135 224697..225017 - 321 WP_077189768.1 helix-turn-helix domain-containing protein -
A8E75_RS01140 225045..225539 - 495 WP_077189767.1 DUF2384 domain-containing protein -
A8E75_RS35545 225529..225753 - 225 WP_125346558.1 hypothetical protein -
A8E75_RS01145 225852..226172 - 321 WP_077189766.1 XRE family transcriptional regulator -
A8E75_RS01150 226172..226387 - 216 WP_077189765.1 type I toxin-antitoxin system SymE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-105)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12988.14 Da        Isoelectric Point: 10.1916

>T73152 WP_077189898.1 NZ_CP019672:223940-224272 [Burkholderia cenocepacia]
MKNWTILYYDERVKRDVFALPKGILASYLRLLETMEEHGADLRMPRSRAMGAGLFELRPRGREGIGRVFYCVQVRYELVI
LHSFVKKTQETPEDELRIARRRMKEVQSNG

Download         Length: 333 bp

>T73152 NZ_CP019672:223940-224272 [Burkholderia cenocepacia]
ATGAAGAACTGGACGATCCTGTACTACGACGAGCGTGTGAAGCGTGATGTGTTTGCGTTGCCCAAGGGCATTCTTGCGAG
CTACCTTCGTCTGCTCGAAACCATGGAGGAACACGGTGCCGATCTACGGATGCCACGTTCGCGCGCAATGGGGGCAGGAT
TGTTTGAATTGCGCCCGCGAGGTCGTGAAGGTATCGGACGCGTGTTTTATTGCGTACAGGTTCGATACGAACTCGTCATC
CTGCATTCGTTCGTCAAGAAGACGCAGGAAACGCCTGAAGACGAATTGCGTATCGCCCGTCGGCGAATGAAGGAGGTACA
AAGTAATGGCTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12025.65 Da        Isoelectric Point: 8.9539

>AT73152 WP_077189769.1 NZ_CP019672:224265-224597 [Burkholderia cenocepacia]
MAKARPARANEDRYVPVRHTAEDTARLLSDPVIKAEYDALEEEFTALRALLDARKEAGLTQAQVAERMGTTTSAVSRLEA
SLSSEKHSPSFSTLRKYAAACGKKLIISFA

Download         Length: 333 bp

>AT73152 NZ_CP019672:224265-224597 [Burkholderia cenocepacia]
ATGGCTAAGGCTCGCCCCGCACGTGCGAACGAGGATCGGTATGTACCTGTCCGGCACACTGCCGAAGATACCGCTCGTTT
GCTCTCTGACCCGGTCATCAAGGCAGAGTACGACGCGCTGGAAGAAGAATTTACCGCGCTTCGCGCATTGCTCGATGCGC
GTAAAGAAGCGGGCTTGACGCAAGCGCAAGTCGCTGAGCGAATGGGAACCACGACATCCGCCGTATCCAGGCTTGAGGCC
TCGCTGTCGAGCGAGAAACATTCACCGTCGTTTTCGACGCTGCGCAAATACGCTGCAGCATGCGGAAAGAAGCTCATTAT
CTCGTTTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References