Detailed information of TA system TA073151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 4975156..4975771
• Replicon: chromosome
• Accession: NZ_CP019670
• Organism: Burkholderia cenocepacia strain VC12802

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: A8E96_RS28025
• Protein ID: WP_077219821.1
• Coordinates: 4975156..4975497 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A8E96_RS28030
• Protein ID: WP_012338842.1
• Coordinates: 4975484..4975771 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8E96_RS27995	4970966..4971385	-	420	WP_053526382.1	secondary thiamine-phosphate synthase enzyme YjbQ	-
A8E96_RS28000	4971396..4971722	-	327	WP_006485487.1	thioredoxin family protein	-
A8E96_RS28005	4971952..4972656	+	705	WP_077219824.1	flavin reductase family protein	-
A8E96_RS34775	4972653..4972802	+	150	WP_155123366.1	hypothetical protein	-
A8E96_RS28010	4972856..4973188	+	333	WP_077219823.1	DUF2322 family protein	-
A8E96_RS28015	4973298..4974164	+	867	WP_077219822.1	hypothetical protein	-
A8E96_RS28020	4974309..4974941	+	633	WP_069230543.1	LysE family translocator	-
A8E96_RS28025	4975156..4975497	+	342	WP_077219821.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A8E96_RS28030	4975484..4975771	+	288	WP_012338842.1	helix-turn-helix domain-containing protein	Antitoxin
A8E96_RS28035	4975854..4976423	-	570	WP_077219820.1	hypothetical protein	-
A8E96_RS28040	4976660..4977118	-	459	WP_006486309.1	Lrp/AsnC family transcriptional regulator	-
A8E96_RS28045	4977244..4977978	+	735	WP_077219819.1	AzlC family ABC transporter permease	-
A8E96_RS28050	4977971..4978279	+	309	WP_011548439.1	AzlD family protein	-
A8E96_RS28055	4978471..4979250	+	780	WP_034202881.1	5'/3'-nucleotidase SurE	-
A8E96_RS28060	4979338..4980159	-	822	WP_077219818.1	SDR family oxidoreductase	-
A8E96_RS28065	4980349..4980729	-	381	WP_077219817.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (20-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-90)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12949.12 Da
• Isoelectric Point: 10.0284

>T73151 WP_077219821.1 NZ_CP019670:4975156-4975497 [Burkholderia cenocepacia]
MPTHGYEIQFFNERVAAGVASLPTTLLARYFALADRMERYGPHLGEPHSQSMGNGLYEMRLKGAEGIARVFYCAIVERRI
VMLHCFVKKTPRTPLKELEIARRRLKEVRDGNV

Nucleotide

• Length: 342 bp

>T73151 NZ_CP019670:4975156-4975497 [Burkholderia cenocepacia]
ATGCCGACTCATGGTTACGAGATCCAGTTCTTCAATGAGCGTGTAGCGGCAGGCGTAGCGTCGTTGCCGACGACGCTGCT
TGCCCGGTACTTTGCACTCGCGGACCGCATGGAACGGTACGGCCCGCATCTCGGGGAACCGCACTCCCAATCGATGGGAA
ACGGCCTGTATGAGATGCGATTGAAAGGCGCGGAAGGTATTGCCCGGGTGTTTTACTGCGCGATCGTCGAACGCCGAATC
GTCATGCTCCACTGTTTCGTGAAGAAGACGCCAAGGACGCCGCTGAAAGAACTGGAAATCGCGCGCCGTCGCTTGAAGGA
GGTTCGAGATGGCAACGTATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10394.94 Da
• Isoelectric Point: 9.6538

>AT73151 WP_012338842.1 NZ_CP019670:4975484-4975771 [Burkholderia cenocepacia]
MATYKELRERALADPAVRTEYERLNREEFALLDAMLAARREAGLSQADVAARMGTKAPAITRLERALATGQHSPSVDTLR
KYAAACGKTLVISFA

Nucleotide

• Length: 288 bp

>AT73151 NZ_CP019670:4975484-4975771 [Burkholderia cenocepacia]
ATGGCAACGTATAAGGAACTACGTGAGCGGGCACTGGCCGATCCCGCGGTGCGCACGGAATACGAACGATTGAATCGCGA
GGAATTCGCGCTGCTCGACGCGATGCTGGCTGCGCGGCGAGAAGCGGGCTTGTCGCAAGCCGACGTGGCGGCACGCATGG
GCACGAAAGCGCCCGCCATTACCCGACTCGAGCGCGCGCTCGCAACGGGGCAGCATTCCCCGTCCGTCGATACGCTGCGC
AAGTATGCGGCGGCTTGCGGCAAGACGCTCGTGATCTCGTTCGCCTGA