Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 2397805..2398534 | Replicon | chromosome |
Accession | NZ_CP019668 | ||
Organism | Burkholderia cenocepacia strain VC7848 |
Toxin (Protein)
Gene name | higB | Uniprot ID | F2LFJ4 |
Locus tag | A8E88_RS11180 | Protein ID | WP_013698487.1 |
Coordinates | 2397805..2398116 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | A8E88_RS11185 | Protein ID | WP_077178237.1 |
Coordinates | 2398118..2398534 (+) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A8E88_RS11165 | 2393830..2394429 | + | 600 | WP_077178239.1 | hypothetical protein | - |
A8E88_RS11170 | 2394537..2396156 | + | 1620 | WP_011549558.1 | glutamine-hydrolyzing GMP synthase | - |
A8E88_RS11175 | 2396468..2397724 | + | 1257 | WP_077178238.1 | tyrosine-type recombinase/integrase | - |
A8E88_RS11180 | 2397805..2398116 | + | 312 | WP_013698487.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
A8E88_RS11185 | 2398118..2398534 | + | 417 | WP_077178237.1 | transcriptional regulator | Antitoxin |
A8E88_RS11190 | 2398716..2399072 | - | 357 | WP_077178236.1 | AlpA family phage regulatory protein | - |
A8E88_RS11195 | 2399149..2399946 | - | 798 | WP_077178235.1 | hypothetical protein | - |
A8E88_RS11200 | 2399958..2400854 | - | 897 | WP_077178234.1 | WYL domain-containing protein | - |
A8E88_RS11205 | 2400944..2402137 | + | 1194 | WP_077178233.1 | metallohydrolase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 2397805..2437568 | 39763 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12258.94 Da Isoelectric Point: 9.6242
>T73136 WP_013698487.1 NZ_CP019668:2397805-2398116 [Burkholderia cenocepacia]
MHVISRKPFSDAAKAYPNDAEAIDRTYRVLRSGDFDTPQALRQVFPSLDNFKYKDKWWVLDIGGNNLRLIAFIEFRDNRM
YVKHITTHAEYDKLCKRYRKEGD
MHVISRKPFSDAAKAYPNDAEAIDRTYRVLRSGDFDTPQALRQVFPSLDNFKYKDKWWVLDIGGNNLRLIAFIEFRDNRM
YVKHITTHAEYDKLCKRYRKEGD
Download Length: 312 bp
>T73136 NZ_CP019668:2397805-2398116 [Burkholderia cenocepacia]
ATGCACGTCATATCCAGAAAGCCGTTCAGCGATGCAGCAAAGGCTTATCCGAACGACGCCGAGGCGATCGACCGCACCTA
TCGGGTGCTGCGATCCGGCGATTTCGATACACCACAGGCACTGCGACAGGTTTTTCCGTCGCTGGATAACTTCAAGTACA
AGGACAAGTGGTGGGTGCTGGACATCGGTGGCAACAATCTTCGACTGATTGCCTTCATCGAGTTTCGCGACAACCGCATG
TACGTCAAGCACATCACAACCCATGCCGAGTACGACAAGCTTTGCAAACGCTACCGGAAGGAGGGCGACTGA
ATGCACGTCATATCCAGAAAGCCGTTCAGCGATGCAGCAAAGGCTTATCCGAACGACGCCGAGGCGATCGACCGCACCTA
TCGGGTGCTGCGATCCGGCGATTTCGATACACCACAGGCACTGCGACAGGTTTTTCCGTCGCTGGATAACTTCAAGTACA
AGGACAAGTGGTGGGTGCTGGACATCGGTGGCAACAATCTTCGACTGATTGCCTTCATCGAGTTTCGCGACAACCGCATG
TACGTCAAGCACATCACAACCCATGCCGAGTACGACAAGCTTTGCAAACGCTACCGGAAGGAGGGCGACTGA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15154.23 Da Isoelectric Point: 4.6805
>AT73136 WP_077178237.1 NZ_CP019668:2398118-2398534 [Burkholderia cenocepacia]
MGFAAIKERAHALFDEAGFIGHIANEDDYAQALALMDELVEDYEANRPLIEILARSIEIWENESDEFAAFNARVAKLGGV
DVLRLLMEQHGLGVADLPEIGSKSLVSKILNGRGRNLTRDHIAALSKRFSVSPAVFFG
MGFAAIKERAHALFDEAGFIGHIANEDDYAQALALMDELVEDYEANRPLIEILARSIEIWENESDEFAAFNARVAKLGGV
DVLRLLMEQHGLGVADLPEIGSKSLVSKILNGRGRNLTRDHIAALSKRFSVSPAVFFG
Download Length: 417 bp
>AT73136 NZ_CP019668:2398118-2398534 [Burkholderia cenocepacia]
ATGGGATTTGCCGCCATCAAGGAACGAGCCCATGCCTTGTTCGACGAGGCGGGTTTCATTGGCCATATCGCCAATGAAGA
TGATTACGCCCAGGCGCTGGCGTTGATGGATGAACTGGTCGAAGACTACGAGGCCAACCGCCCACTGATCGAGATCCTGG
CCCGTTCCATCGAGATCTGGGAAAACGAGTCCGATGAGTTTGCGGCATTCAACGCGCGCGTGGCGAAGCTGGGTGGCGTC
GACGTGCTCCGGCTGCTGATGGAGCAGCATGGGTTGGGCGTGGCCGACCTGCCGGAGATTGGGAGCAAGTCGCTGGTGTC
GAAGATTCTCAATGGCCGAGGCCGCAACTTGACTCGCGACCACATCGCGGCATTGAGCAAGCGGTTCTCAGTCAGCCCGG
CTGTTTTCTTCGGCTAA
ATGGGATTTGCCGCCATCAAGGAACGAGCCCATGCCTTGTTCGACGAGGCGGGTTTCATTGGCCATATCGCCAATGAAGA
TGATTACGCCCAGGCGCTGGCGTTGATGGATGAACTGGTCGAAGACTACGAGGCCAACCGCCCACTGATCGAGATCCTGG
CCCGTTCCATCGAGATCTGGGAAAACGAGTCCGATGAGTTTGCGGCATTCAACGCGCGCGTGGCGAAGCTGGGTGGCGTC
GACGTGCTCCGGCTGCTGATGGAGCAGCATGGGTTGGGCGTGGCCGACCTGCCGGAGATTGGGAGCAAGTCGCTGGTGTC
GAAGATTCTCAATGGCCGAGGCCGCAACTTGACTCGCGACCACATCGCGGCATTGAGCAAGCGGTTCTCAGTCAGCCCGG
CTGTTTTCTTCGGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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