Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2397805..2398534 Replicon chromosome
Accession NZ_CP019668
Organism Burkholderia cenocepacia strain VC7848

Toxin (Protein)


Gene name higB Uniprot ID F2LFJ4
Locus tag A8E88_RS11180 Protein ID WP_013698487.1
Coordinates 2397805..2398116 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A8E88_RS11185 Protein ID WP_077178237.1
Coordinates 2398118..2398534 (+) Length 139 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8E88_RS11165 2393830..2394429 + 600 WP_077178239.1 hypothetical protein -
A8E88_RS11170 2394537..2396156 + 1620 WP_011549558.1 glutamine-hydrolyzing GMP synthase -
A8E88_RS11175 2396468..2397724 + 1257 WP_077178238.1 tyrosine-type recombinase/integrase -
A8E88_RS11180 2397805..2398116 + 312 WP_013698487.1 type II toxin-antitoxin system HigB family toxin Toxin
A8E88_RS11185 2398118..2398534 + 417 WP_077178237.1 transcriptional regulator Antitoxin
A8E88_RS11190 2398716..2399072 - 357 WP_077178236.1 AlpA family phage regulatory protein -
A8E88_RS11195 2399149..2399946 - 798 WP_077178235.1 hypothetical protein -
A8E88_RS11200 2399958..2400854 - 897 WP_077178234.1 WYL domain-containing protein -
A8E88_RS11205 2400944..2402137 + 1194 WP_077178233.1 metallohydrolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2397805..2437568 39763


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12258.94 Da        Isoelectric Point: 9.6242

>T73136 WP_013698487.1 NZ_CP019668:2397805-2398116 [Burkholderia cenocepacia]
MHVISRKPFSDAAKAYPNDAEAIDRTYRVLRSGDFDTPQALRQVFPSLDNFKYKDKWWVLDIGGNNLRLIAFIEFRDNRM
YVKHITTHAEYDKLCKRYRKEGD

Download         Length: 312 bp

>T73136 NZ_CP019668:2397805-2398116 [Burkholderia cenocepacia]
ATGCACGTCATATCCAGAAAGCCGTTCAGCGATGCAGCAAAGGCTTATCCGAACGACGCCGAGGCGATCGACCGCACCTA
TCGGGTGCTGCGATCCGGCGATTTCGATACACCACAGGCACTGCGACAGGTTTTTCCGTCGCTGGATAACTTCAAGTACA
AGGACAAGTGGTGGGTGCTGGACATCGGTGGCAACAATCTTCGACTGATTGCCTTCATCGAGTTTCGCGACAACCGCATG
TACGTCAAGCACATCACAACCCATGCCGAGTACGACAAGCTTTGCAAACGCTACCGGAAGGAGGGCGACTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15154.23 Da        Isoelectric Point: 4.6805

>AT73136 WP_077178237.1 NZ_CP019668:2398118-2398534 [Burkholderia cenocepacia]
MGFAAIKERAHALFDEAGFIGHIANEDDYAQALALMDELVEDYEANRPLIEILARSIEIWENESDEFAAFNARVAKLGGV
DVLRLLMEQHGLGVADLPEIGSKSLVSKILNGRGRNLTRDHIAALSKRFSVSPAVFFG

Download         Length: 417 bp

>AT73136 NZ_CP019668:2398118-2398534 [Burkholderia cenocepacia]
ATGGGATTTGCCGCCATCAAGGAACGAGCCCATGCCTTGTTCGACGAGGCGGGTTTCATTGGCCATATCGCCAATGAAGA
TGATTACGCCCAGGCGCTGGCGTTGATGGATGAACTGGTCGAAGACTACGAGGCCAACCGCCCACTGATCGAGATCCTGG
CCCGTTCCATCGAGATCTGGGAAAACGAGTCCGATGAGTTTGCGGCATTCAACGCGCGCGTGGCGAAGCTGGGTGGCGTC
GACGTGCTCCGGCTGCTGATGGAGCAGCATGGGTTGGGCGTGGCCGACCTGCCGGAGATTGGGAGCAAGTCGCTGGTGTC
GAAGATTCTCAATGGCCGAGGCCGCAACTTGACTCGCGACCACATCGCGGCATTGAGCAAGCGGTTCTCAGTCAGCCCGG
CTGTTTTCTTCGGCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB F2LFJ4


Antitoxin

Source ID Structure

References