73086

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2089988..2090490 Replicon chromosome
Accession NZ_CP019629
Organism Escherichia coli strain MGY

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag BWL12_RS11145 Protein ID WP_000767829.1
Coordinates 2089988..2090242 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag BWL12_RS11150 Protein ID WP_001259255.1
Coordinates 2090239..2090490 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWL12_RS11120 2085003..2085230 - 228 WP_000234896.1 sulfurtransferase TusA -
BWL12_RS11125 2085244..2086302 - 1059 WP_000492339.1 transport protein YeeE -
BWL12_RS11130 2086481..2087839 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
BWL12_RS24455 2087829..2087891 - 63 WP_010723108.1 membrane protein YoeI -
BWL12_RS11135 2088106..2089035 - 930 WP_000803351.1 LysR family transcriptional regulator -
BWL12_RS11140 2089081..2089905 - 825 WP_000754737.1 SDR family oxidoreductase -
BWL12_RS11145 2089988..2090242 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
BWL12_RS11150 2090239..2090490 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
BWL12_RS11155 2090773..2090823 + 51 WP_001364200.1 his operon leader peptide -
BWL12_RS11165 2090969..2091868 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
BWL12_RS11170 2091874..2093178 + 1305 WP_000009594.1 histidinol dehydrogenase -
BWL12_RS11175 2093175..2094245 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
BWL12_RS11180 2094245..2095312 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T73086 WP_000767829.1 NZ_CP019629:c2090242-2089988 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T73086 NZ_CP019629:c2090242-2089988 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT73086 WP_001259255.1 NZ_CP019629:c2090490-2090239 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT73086 NZ_CP019629:c2090490-2090239 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References