Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 3755515..3756163 Replicon chromosome
Accession NZ_CP019611
Organism Mycobacterium tuberculosis strain H83

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag B0W95_RS18170 Protein ID WP_003899414.1
Coordinates 3755515..3755838 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag B0W95_RS18175 Protein ID WP_003899415.1
Coordinates 3755918..3756163 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W95_RS18140 3750838..3751836 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
B0W95_RS18145 3751850..3752314 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
B0W95_RS18150 3752302..3752553 + 252 WP_003908028.1 hypothetical protein -
B0W95_RS18155 3752724..3754163 - 1440 WP_003899411.1 phage major capsid protein -
B0W95_RS18160 3754171..3754704 - 534 WP_003899412.1 HK97 family phage prohead protease -
B0W95_RS18165 3754857..3755483 - 627 WP_003899413.1 phage terminase small subunit P27 family -
B0W95_RS18170 3755515..3755838 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
B0W95_RS18175 3755918..3756163 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
B0W95_RS18180 3756160..3757587 - 1428 WP_112704285.1 DUF3631 domain-containing protein -
B0W95_RS18185 3757589..3757981 - 393 WP_003899417.1 DUF2742 domain-containing protein -
B0W95_RS18190 3757978..3758238 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
B0W95_RS18195 3758255..3758617 - 363 WP_003900543.1 hypothetical protein -
B0W95_RS18200 3758620..3759747 - 1128 WP_003899420.1 site-specific integrase -
B0W95_RS18205 3759892..3760119 - 228 WP_003899421.1 hypothetical protein -
B0W95_RS18210 3760116..3760505 - 390 WP_003899422.1 hypothetical protein -
B0W95_RS18215 3760411..3760683 + 273 WP_003900544.1 hypothetical protein -
B0W95_RS18220 3760782..3761015 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3750838..3759747 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-137)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T72927 WP_003899414.1 NZ_CP019611:c3755838-3755515 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T72927 NZ_CP019611:c3755838-3755515 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT72927 WP_003899415.1 NZ_CP019611:c3756163-3755918 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT72927 NZ_CP019611:c3756163-3755918 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References