Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 3988714..3989362 Replicon chromosome
Accession NZ_CP019610
Organism Mycobacterium tuberculosis strain H54

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag B0W97_RS19410 Protein ID WP_003899414.1
Coordinates 3989039..3989362 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag B0W97_RS19405 Protein ID WP_003899415.1
Coordinates 3988714..3988959 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W97_RS19360 3983862..3984095 - 234 WP_003413717.1 hypothetical protein -
B0W97_RS19365 3984194..3984466 - 273 WP_003900544.1 hypothetical protein -
B0W97_RS19370 3984372..3984761 + 390 WP_003899422.1 hypothetical protein -
B0W97_RS19375 3984758..3984985 + 228 WP_003899421.1 hypothetical protein -
B0W97_RS19380 3985130..3986257 + 1128 WP_003899420.1 site-specific integrase -
B0W97_RS19385 3986260..3986622 + 363 WP_003900543.1 hypothetical protein -
B0W97_RS19390 3986639..3986899 + 261 WP_003899418.1 helix-turn-helix domain-containing protein -
B0W97_RS19395 3986896..3987288 + 393 WP_003899417.1 DUF2742 domain-containing protein -
B0W97_RS19400 3987290..3988717 + 1428 WP_003899416.1 DUF3631 domain-containing protein -
B0W97_RS19405 3988714..3988959 + 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
B0W97_RS19410 3989039..3989362 + 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
B0W97_RS19415 3989394..3990020 + 627 WP_003899413.1 phage terminase small subunit P27 family -
B0W97_RS19420 3990173..3990706 + 534 WP_003899412.1 HK97 family phage prohead protease -
B0W97_RS19425 3990714..3992153 + 1440 WP_003901443.1 phage major capsid protein -
B0W97_RS19430 3992324..3992575 - 252 WP_003908028.1 hypothetical protein -
B0W97_RS19435 3992563..3993027 - 465 WP_003900539.1 ParB N-terminal domain-containing protein -
B0W97_RS19440 3993041..3994039 - 999 WP_003900538.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3985130..3994039 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-137)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T72868 WP_003899414.1 NZ_CP019610:3989039-3989362 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T72868 NZ_CP019610:3989039-3989362 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT72868 WP_003899415.1 NZ_CP019610:3988714-3988959 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT72868 NZ_CP019610:3988714-3988959 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References