Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2236892..2237462 Replicon chromosome
Accession NZ_CP019605
Organism Tessaracoccus flavus strain RP1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag RPIT_RS10345 Protein ID WP_077342949.1
Coordinates 2237181..2237462 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RPIT_RS10340 Protein ID WP_077342947.1
Coordinates 2236892..2237194 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RPIT_RS10310 2232311..2233129 - 819 WP_162274537.1 alpha/beta hydrolase -
RPIT_RS10315 2233471..2233992 - 522 WP_162274538.1 ATP-binding protein -
RPIT_RS10320 2233989..2234291 - 303 WP_077342941.1 HigA family addiction module antidote protein -
RPIT_RS10325 2234278..2234559 - 282 WP_077342943.1 type II toxin-antitoxin system RelE/ParE family toxin -
RPIT_RS10330 2234759..2236207 + 1449 WP_176789301.1 IS1634 family transposase -
RPIT_RS10335 2236401..2236895 - 495 WP_044496367.1 hypothetical protein -
RPIT_RS10340 2236892..2237194 - 303 WP_077342947.1 HigA family addiction module antidote protein Antitoxin
RPIT_RS10345 2237181..2237462 - 282 WP_077342949.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RPIT_RS10350 2237544..2238344 - 801 WP_143028191.1 response regulator -
RPIT_RS10355 2238341..2238871 - 531 WP_077342953.1 hypothetical protein -
RPIT_RS10360 2238876..2239730 - 855 WP_143028190.1 hypothetical protein -
RPIT_RS10365 2239727..2240818 - 1092 WP_077342957.1 redox-regulated ATPase YchF -
RPIT_RS10370 2241102..2242049 + 948 WP_077342958.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11091.53 Da        Isoelectric Point: 10.6413

>T72812 WP_077342949.1 NZ_CP019605:c2237462-2237181 [Tessaracoccus flavus]
VIRSFGSKDTERLWRRERVRSIYHRIHRVALRKLRQVGSAESIEDLRVPPGNRFEALKGDRAGQHSIRINDEWRIWFVRT
DAGPEEVEIVDYH

Download         Length: 282 bp

>T72812 NZ_CP019605:c2237462-2237181 [Tessaracoccus flavus]
GTGATCAGATCGTTCGGGAGCAAGGACACCGAACGATTGTGGCGTCGTGAGCGAGTGCGCTCGATCTATCATCGGATCCA
TCGGGTCGCACTGCGCAAGCTTCGTCAGGTGGGATCGGCGGAGTCCATCGAGGATCTTCGGGTCCCGCCGGGCAACCGGT
TCGAAGCGCTGAAGGGCGACCGCGCCGGGCAGCACAGCATCAGGATCAACGACGAGTGGCGGATCTGGTTCGTGCGGACC
GACGCAGGACCGGAGGAGGTGGAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10972.62 Da        Isoelectric Point: 4.7628

>AT72812 WP_077342947.1 NZ_CP019605:c2237194-2236892 [Tessaracoccus flavus]
MTTTEKIAPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLGKLFGTTAQFWLNLQTLYDL
DLAEDRAAEQIDAIVPLQSA

Download         Length: 303 bp

>AT72812 NZ_CP019605:c2237194-2236892 [Tessaracoccus flavus]
TTGACTACCACTGAGAAGATTGCCCCGATCCACCCTGGGGAGGTCCTCATGGAGGACTTCATCGAGGGCTTCGGGATCAC
GCAGAACAAGCTCGCCGTGTCGATCGGCGTCCCGCCTCGGCGGATCAACGAGATCGTGCATGGCAAGCGGGGGATCACGG
CGGACACCGCGCTCCGGCTCGGCAAGCTCTTCGGCACCACCGCACAGTTCTGGCTGAACCTGCAGACGCTCTACGACCTC
GACCTCGCAGAGGATCGCGCGGCTGAGCAGATCGACGCCATCGTGCCGCTGCAATCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References