Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2233989..2234559 Replicon chromosome
Accession NZ_CP019605
Organism Tessaracoccus flavus strain RP1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag RPIT_RS10325 Protein ID WP_077342943.1
Coordinates 2234278..2234559 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RPIT_RS10320 Protein ID WP_077342941.1
Coordinates 2233989..2234291 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RPIT_RS10295 2229180..2230592 - 1413 WP_077342931.1 HNH endonuclease -
RPIT_RS10300 2231033..2231563 - 531 WP_077342933.1 GNAT family N-acetyltransferase -
RPIT_RS10305 2231711..2232211 - 501 WP_077342935.1 Lrp/AsnC family transcriptional regulator -
RPIT_RS10310 2232311..2233129 - 819 WP_162274537.1 alpha/beta hydrolase -
RPIT_RS10315 2233471..2233992 - 522 WP_162274538.1 ATP-binding protein -
RPIT_RS10320 2233989..2234291 - 303 WP_077342941.1 HigA family addiction module antidote protein Antitoxin
RPIT_RS10325 2234278..2234559 - 282 WP_077342943.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RPIT_RS10330 2234759..2236207 + 1449 WP_176789301.1 IS1634 family transposase -
RPIT_RS10335 2236401..2236895 - 495 WP_044496367.1 hypothetical protein -
RPIT_RS10340 2236892..2237194 - 303 WP_077342947.1 HigA family addiction module antidote protein -
RPIT_RS10345 2237181..2237462 - 282 WP_077342949.1 type II toxin-antitoxin system RelE/ParE family toxin -
RPIT_RS10350 2237544..2238344 - 801 WP_143028191.1 response regulator -
RPIT_RS10355 2238341..2238871 - 531 WP_077342953.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-85)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10886.43 Da        Isoelectric Point: 10.9360

>T72811 WP_077342943.1 NZ_CP019605:c2234559-2234278 [Tessaracoccus flavus]
VIRSFGDKETERLWRRERMRSIGPRIHRVALRKLRQVGSAESIEDLRVPPGNRLEALKGDRAGQHSIRINDQWRICFVWT
AAGPEEVQIVDYH

Download         Length: 282 bp

>T72811 NZ_CP019605:c2234559-2234278 [Tessaracoccus flavus]
GTGATCAGATCGTTCGGCGACAAGGAGACCGAACGGCTGTGGCGTCGTGAACGCATGAGGTCGATTGGTCCGAGGATCCA
TCGAGTCGCATTGCGCAAGCTTCGTCAGGTGGGGTCCGCGGAGTCCATCGAGGACCTCCGTGTCCCACCCGGCAACCGCC
TCGAAGCTCTCAAGGGCGACCGTGCCGGGCAGCACAGCATCAGGATCAACGACCAGTGGCGGATCTGCTTCGTGTGGACC
GCCGCCGGACCAGAGGAGGTGCAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11046.61 Da        Isoelectric Point: 5.1100

>AT72811 WP_077342941.1 NZ_CP019605:c2234291-2233989 [Tessaracoccus flavus]
MTTTDKIEPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSAEFWINLQSHYEL
DRAEDQAGEQIAAIAPLKIA

Download         Length: 303 bp

>AT72811 NZ_CP019605:c2234291-2233989 [Tessaracoccus flavus]
TTGACTACCACTGACAAGATCGAGCCGATCCACCCGGGCGAGGTGCTCATGGAGGACTTCATCGAGGGCTTCGGCATCAC
GCAGAACAAGCTCGCCGTATCCATCGGCGTCCCGCCTCGGCGGATCAACGAGATCGTGCATGGCAAGCGGGGGATCACGG
CGGATACAGCGTTGCGACTTGCGAAGTACTTCGGTACCTCGGCGGAGTTCTGGATCAACCTGCAGAGCCACTACGAGTTG
GACCGCGCCGAGGACCAGGCGGGGGAGCAGATCGCAGCGATCGCCCCGCTGAAGATCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References