Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 240206..240834 Replicon plasmid pCME4A9I
Accession NZ_CP019603
Organism Croceicoccus marinus strain E4A9

Toxin (Protein)


Gene name higB Uniprot ID A0A1Z1FG23
Locus tag A9D14_RS15410 Protein ID WP_066849897.1
Coordinates 240493..240834 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1Z1FGB0
Locus tag A9D14_RS15405 Protein ID WP_066849894.1
Coordinates 240206..240496 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9D14_RS15375 235269..236282 - 1014 WP_066850665.1 hypothetical protein -
A9D14_RS15380 236611..236910 - 300 WP_066849884.1 hypothetical protein -
A9D14_RS19640 237519..237728 - 210 WP_157668268.1 hypothetical protein -
A9D14_RS15385 237729..238277 - 549 WP_157668269.1 SOS response-associated peptidase family protein -
A9D14_RS15390 238544..239215 + 672 WP_066849886.1 thermonuclease family protein -
A9D14_RS15395 239375..239995 + 621 WP_066849888.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
A9D14_RS15405 240206..240496 - 291 WP_066849894.1 helix-turn-helix domain-containing protein Antitoxin
A9D14_RS15410 240493..240834 - 342 WP_066849897.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9D14_RS15415 241178..241324 - 147 Protein_236 transposase -
A9D14_RS15420 241438..242975 + 1538 Protein_237 IS21 family transposase -
A9D14_RS15425 242965..243744 + 780 WP_066843517.1 IS21-like element helper ATPase IstB -
A9D14_RS15430 243886..244197 + 312 WP_083988106.1 hypothetical protein -
A9D14_RS15435 244490..244975 - 486 WP_066849900.1 PilZ domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..761621 761621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(21-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-74)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12261.29 Da        Isoelectric Point: 10.2236

>T72809 WP_066849897.1 NZ_CP019603:c240834-240493 [Croceicoccus marinus]
MANLQIVVELPEFLRRAKAIMSDEDRTALVNYIAANPEAGVSLGGGLRKVRIARQGGGKSGGYRTIYVFGGVQVPIFLVT
VFAKKEKDNLTKAEQADLIAMSKVLLAHYGDRP

Download         Length: 342 bp

>T72809 NZ_CP019603:c240834-240493 [Croceicoccus marinus]
ATGGCTAACCTGCAGATTGTAGTGGAATTACCCGAATTTCTGCGGAGGGCCAAGGCGATCATGTCCGATGAGGATCGAAC
GGCGCTGGTCAATTACATTGCCGCCAATCCAGAGGCAGGTGTTTCACTGGGCGGAGGTCTTCGTAAAGTCCGTATCGCCC
GGCAGGGCGGCGGTAAAAGCGGCGGCTACCGGACTATCTATGTGTTCGGCGGCGTGCAGGTTCCCATCTTCCTTGTCACC
GTATTCGCCAAGAAGGAAAAGGATAACCTGACCAAAGCGGAGCAGGCAGATTTGATCGCTATGAGCAAAGTTCTGCTCGC
ACATTATGGAGACCGACCATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10162.71 Da        Isoelectric Point: 10.4550

>AT72809 WP_066849894.1 NZ_CP019603:c240496-240206 [Croceicoccus marinus]
MTAYDSIKQGLSEALAFTEGNEAGAQIHQVEVPAVDVAAIRASTGLSQGAFARSIGVAKGTLLNWEHGRRRPTGPAQVLL
AMIAKKPSLVRELLRP

Download         Length: 291 bp

>AT72809 NZ_CP019603:c240496-240206 [Croceicoccus marinus]
ATGACCGCCTATGACAGCATCAAGCAAGGTCTGAGCGAAGCGTTGGCGTTTACGGAAGGCAACGAGGCCGGAGCGCAGAT
CCATCAGGTGGAAGTGCCGGCCGTCGACGTTGCCGCGATACGCGCCAGCACCGGCCTCTCGCAGGGCGCGTTCGCGCGCA
GCATCGGCGTTGCCAAAGGCACGCTGCTCAATTGGGAACATGGCCGCCGCCGTCCTACTGGCCCAGCGCAGGTGCTGCTC
GCGATGATCGCCAAGAAGCCTTCGTTGGTGCGTGAATTGCTGCGTCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z1FG23

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1FGB0

References