Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2185614..2185877 Replicon chromosome
Accession NZ_CP019595
Organism Staphylococcus aureus strain GD1677

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag BZK09_RS11140 Protein ID WP_001802298.1
Coordinates 2185773..2185877 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2185614..2185778 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZK09_RS11120 2181799..2182464 - 666 WP_001024099.1 SDR family oxidoreductase -
BZK09_RS11125 2182616..2182936 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
BZK09_RS11130 2182938..2183918 + 981 WP_031886446.1 CDF family zinc efflux transporter CzrB -
BZK09_RS11135 2184184..2185275 + 1092 WP_000495673.1 hypothetical protein -
- 2185614..2185778 + 165 - - Antitoxin
BZK09_RS11140 2185773..2185877 - 105 WP_001802298.1 hypothetical protein Toxin
BZK09_RS11155 2186557..2186715 + 159 WP_001792784.1 hypothetical protein -
BZK09_RS11160 2187151..2187243 + 93 WP_000220902.1 hypothetical protein -
BZK09_RS11165 2187373..2188230 - 858 WP_000370942.1 Cof-type HAD-IIB family hydrolase -
BZK09_RS11170 2188298..2189080 - 783 WP_000908191.1 ABC transporter ATP-binding protein -
BZK09_RS11175 2189370..2189978 - 609 WP_000101714.1 TIR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T72802 WP_001802298.1 NZ_CP019595:c2185877-2185773 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T72802 NZ_CP019595:c2185877-2185773 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT72802 NZ_CP019595:2185614-2185778 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References