Detailed information of TA system TA072796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 405643..406057
• Replicon: chromosome
• Accession: NZ_CP019595
• Organism: Staphylococcus aureus strain GD1677

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BZK09_RS01975
• Protein ID: WP_031886311.1
• Coordinates: 405643..405894 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BZK09_RS14285
• Protein ID: WP_000028424.1
• Coordinates: 405884..406057 (+)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZK09_RS01920	400845..402797	+	1953	WP_001796208.1	DNA polymerase	-
BZK09_RS01925	402810..402995	+	186	WP_001164628.1	DUF3113 family protein	-
BZK09_RS01930	402995..403396	+	402	WP_000113981.1	PVL family protein	-
BZK09_RS01935	403396..403653	+	258	WP_000111488.1	DUF3310 domain-containing protein	-
BZK09_RS01940	403656..403856	+	201	WP_031796775.1	hypothetical protein	-
BZK09_RS01945	403865..404113	+	249	WP_000178883.1	phi PVL orf 51-like protein	-
BZK09_RS01950	404128..404334	+	207	WP_000693993.1	hypothetical protein	-
BZK09_RS01955	404337..404744	+	408	WP_000695771.1	hypothetical protein	-
BZK09_RS01960	404741..404935	+	195	WP_031794818.1	hypothetical protein	-
BZK09_RS01965	404932..405369	+	438	WP_031796778.1	hypothetical protein	-
BZK09_RS01970	405366..405650	+	285	WP_031886310.1	hypothetical protein	-
BZK09_RS01975	405643..405894	+	252	WP_031886311.1	DUF1024 family protein	Toxin
BZK09_RS14285	405884..406057	+	174	WP_000028424.1	hypothetical protein	Antitoxin
BZK09_RS14290	406058..406219	+	162	WP_000889680.1	hypothetical protein	-
BZK09_RS01980	406234..406740	+	507	WP_001061834.1	dUTPase	-
BZK09_RS01985	406777..406983	+	207	WP_031886312.1	DUF1381 domain-containing protein	-
BZK09_RS01990	406980..407174	+	195	WP_000141184.1	hypothetical protein	-
BZK09_RS01995	407171..407374	+	204	WP_001072795.1	hypothetical protein	-
BZK09_RS02000	407367..407519	+	153	WP_031767608.1	transcriptional activator RinB	-
BZK09_RS02005	407587..407787	+	201	WP_031886313.1	DUF1514 family protein	-
BZK09_RS02010	407839..410286	+	2448	WP_031886314.1	virulence-associated E family protein	-
BZK09_RS02020	410388..410492	-	105	WP_078098968.1	hypothetical protein	-
BZK09_RS02025	410626..410916	+	291	WP_000665205.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	392684..440025	47341

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9405.28 Da
• Isoelectric Point: 3.8567

>T72796 WP_031886311.1 NZ_CP019595:405643-405894 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMTGQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T72796 NZ_CP019595:405643-405894 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATACAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT72796 WP_000028424.1 NZ_CP019595:405884-406057 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT72796 NZ_CP019595:405884-406057 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA