Detailed information of TA system TA072793

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 396940..397519
• Replicon: chromosome
• Accession: NZ_CP019595
• Organism: Staphylococcus aureus strain GD1677

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: BZK09_RS01875
• Protein ID: WP_001025401.1
• Coordinates: 396940..397185 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	397154..397519 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZK09_RS01840	392684..393889	-	1206	WP_031883891.1	site-specific integrase	-
BZK09_RS01845	393999..394622	+	624	WP_001166482.1	hypothetical protein	-
BZK09_RS01850	394820..395215	-	396	WP_000449655.1	hypothetical protein	-
BZK09_RS01855	395244..395678	-	435	WP_000755721.1	hypothetical protein	-
BZK09_RS01860	395696..396157	-	462	WP_031886309.1	toxin	-
BZK09_RS01865	396170..396499	-	330	WP_000429766.1	helix-turn-helix domain-containing protein	-
BZK09_RS01870	396660..396851	+	192	WP_001115060.1	helix-turn-helix domain-containing protein	-
BZK09_RS01875	396940..397185	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
BZK09_RS01880	397154..397519	-	366	WP_001128433.1	hypothetical protein	Antitoxin
BZK09_RS01885	397574..397789	+	216	WP_001036302.1	hypothetical protein	-
BZK09_RS01890	397814..398077	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
BZK09_RS01895	398090..398251	+	162	WP_001285963.1	DUF1270 family protein	-
BZK09_RS01900	398330..398653	+	324	WP_000175000.1	hypothetical protein	-
BZK09_RS01905	398668..399030	+	363	WP_000279445.1	hypothetical protein	-
BZK09_RS01910	399027..400193	+	1167	WP_000762532.1	DUF2800 domain-containing protein	-
BZK09_RS01915	400219..400776	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	392684..440025	47341

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T72793 WP_001025401.1 NZ_CP019595:396940-397185 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T72793 NZ_CP019595:396940-397185 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT72793 NZ_CP019595:c397519-397154 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin