Detailed information of TA system TA072791

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2484275..2484459
• Replicon: chromosome
• Accession: NZ_CP019594
• Organism: Staphylococcus aureus strain GD1539

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: BZK08_RS12955
• Protein ID: WP_000482647.1
• Coordinates: 2484352..2484459 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2484275..2484335 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZK08_RS12930	2479729..2479896	-	168	WP_001798790.1	hypothetical protein	-
BZK08_RS12940	2480127..2481860	-	1734	WP_000486511.1	ABC transporter ATP-binding protein/permease	-
BZK08_RS12945	2481885..2483648	-	1764	WP_084568239.1	ABC transporter ATP-binding protein/permease	-
-	2484275..2484335	+	61	-	-	Antitoxin
BZK08_RS12955	2484352..2484459	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
BZK08_RS12960	2484593..2484979	-	387	WP_000779355.1	flippase GtxA	-
BZK08_RS12965	2485246..2486388	+	1143	WP_001176859.1	glycerate kinase	-
BZK08_RS12970	2486448..2487107	+	660	WP_000831300.1	hypothetical protein	-
BZK08_RS12975	2487295..2488506	+	1212	WP_001191974.1	multidrug effflux MFS transporter	-
BZK08_RS12980	2488629..2489102	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-99)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T72791 WP_000482647.1 NZ_CP019594:c2484459-2484352 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T72791 NZ_CP019594:c2484459-2484352 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT72791 NZ_CP019594:2484275-2484335 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin