Detailed information of TA system TA072789

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2188857..2189074
• Replicon: chromosome
• Accession: NZ_CP019594
• Organism: Staphylococcus aureus strain GD1539

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: BZK08_RS11335
• Protein ID: WP_001802298.1
• Coordinates: 2188970..2189074 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2188857..2188912 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZK08_RS11315	2184996..2185661	-	666	WP_001024099.1	SDR family oxidoreductase	-
BZK08_RS11320	2185813..2186133	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
BZK08_RS11325	2186135..2187115	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
BZK08_RS11330	2187381..2188472	+	1092	WP_000495673.1	hypothetical protein	-
-	2188857..2188912	+	56	-	-	Antitoxin
BZK08_RS11335	2188970..2189074	-	105	WP_001802298.1	hypothetical protein	Toxin
BZK08_RS11350	2189754..2189912	+	159	WP_001792784.1	hypothetical protein	-
BZK08_RS11355	2190348..2190440	+	93	WP_000220902.1	hypothetical protein	-
BZK08_RS11360	2190570..2191427	-	858	WP_000370942.1	Cof-type HAD-IIB family hydrolase	-
BZK08_RS11365	2191495..2192277	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
BZK08_RS11370	2192567..2193175	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (76-174)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T72789 WP_001802298.1 NZ_CP019594:c2189074-2188970 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T72789 NZ_CP019594:c2189074-2188970 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT72789 NZ_CP019594:2188857-2188912 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin