Detailed information of TA system TA072786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 2037453..2037876
• Replicon: chromosome
• Accession: NZ_CP019594
• Organism: Staphylococcus aureus strain GD1539

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BZK08_RS10480
• Protein ID: WP_084568219.1
• Coordinates: 2037625..2037876 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BZK08_RS10475
• Protein ID: WP_000028421.1
• Coordinates: 2037453..2037635 (-)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZK08_RS10430	2033691..2034035	-	345	WP_000402904.1	hypothetical protein	-
BZK08_RS10435	2034165..2034464	-	300	WP_000988330.1	HNH endonuclease	-
BZK08_RS10440	2034696..2035112	-	417	WP_000590122.1	hypothetical protein	-
BZK08_RS10445	2035140..2035340	-	201	WP_000265041.1	DUF1514 family protein	-
BZK08_RS10450	2035340..2035990	-	651	WP_001005262.1	hypothetical protein	-
BZK08_RS10455	2036149..2036298	-	150	WP_070030217.1	transcriptional regulator	-
BZK08_RS10460	2036311..2036769	-	459	WP_031768021.1	hypothetical protein	-
BZK08_RS10465	2036762..2036914	-	153	WP_031768020.1	DUF1381 domain-containing protein	-
BZK08_RS10470	2036951..2037460	-	510	WP_031866561.1	dUTP pyrophosphatase	-
BZK08_RS10475	2037453..2037635	-	183	WP_000028421.1	hypothetical protein	Antitoxin
BZK08_RS10480	2037625..2037876	-	252	WP_084568219.1	DUF1024 family protein	Toxin
BZK08_RS10485	2037869..2038237	-	369	WP_113624722.1	acetyltransferase	-
BZK08_RS10490	2038246..2038488	-	243	WP_072467409.1	phi PVL orf 51-like protein	-
BZK08_RS10495	2038492..2038860	-	369	WP_000101275.1	hypothetical protein	-
BZK08_RS10500	2038873..2039277	-	405	WP_029052043.1	RusA family crossover junction endodeoxyribonuclease	-
BZK08_RS10505	2039286..2039504	-	219	WP_000338528.1	hypothetical protein	-
BZK08_RS10510	2039511..2040362	-	852	WP_070956221.1	DnaD domain protein	-
BZK08_RS10515	2040392..2040862	-	471	WP_017466775.1	single-stranded DNA-binding protein	-
BZK08_RS10520	2040863..2041480	-	618	WP_071621397.1	MBL fold metallo-hydrolase	-
BZK08_RS10525	2041561..2042481	-	921	WP_084568172.1	recombinase RecT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / scn / chp / sak / hlb / groEL	2008834..2063669	54835

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9473.35 Da
• Isoelectric Point: 3.7951

>T72786 WP_084568219.1 NZ_CP019594:c2037876-2037625 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKDIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTSQVVYKYEEEQE
NEH

Nucleotide

• Length: 252 bp

>T72786 NZ_CP019594:c2037876-2037625 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATCGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGATATTGAAGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGAGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6683.59 Da
• Isoelectric Point: 4.3791

>AT72786 WP_000028421.1 NZ_CP019594:c2037635-2037453 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND

Nucleotide

• Length: 183 bp

>AT72786 NZ_CP019594:c2037635-2037453 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA