Detailed information of TA system TA072783

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2014557..2014864
• Replicon: chromosome
• Accession: NZ_CP019594
• Organism: Staphylococcus aureus strain GD1539

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: BZK08_RS10335
• Protein ID: WP_011447039.1
• Coordinates: 2014688..2014864 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2014557..2014696 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZK08_RS10290	2009896..2010156	+	261	WP_001791826.1	hypothetical protein	-
BZK08_RS10295	2010209..2010559	-	351	WP_084568216.1	complement inhibitor SCIN-A	-
BZK08_RS10300	2011244..2011693	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
BZK08_RS10305	2011788..2012123	-	336	Protein_1907	SH3 domain-containing protein	-
BZK08_RS10315	2012773..2013264	-	492	WP_000919350.1	staphylokinase	-
BZK08_RS10320	2013455..2014210	-	756	WP_000861038.1	CHAP domain-containing protein	-
BZK08_RS10325	2014222..2014476	-	255	WP_000611512.1	phage holin	-
BZK08_RS10330	2014528..2014635	+	108	WP_001791821.1	hypothetical protein	-
-	2014557..2014696	+	140	NuclAT_0	-	Antitoxin
-	2014557..2014696	+	140	NuclAT_0	-	Antitoxin
-	2014557..2014696	+	140	NuclAT_0	-	Antitoxin
-	2014557..2014696	+	140	NuclAT_0	-	Antitoxin
BZK08_RS10335	2014688..2014864	-	177	WP_011447039.1	putative holin-like toxin	Toxin
BZK08_RS10340	2015014..2015310	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
BZK08_RS10345	2015368..2015655	-	288	WP_084568217.1	hypothetical protein	-
BZK08_RS10350	2015702..2015854	-	153	WP_001153681.1	hypothetical protein	-
BZK08_RS10355	2015844..2019629	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / scn / chp / sak / hlb / groEL	2008834..2063669	54835

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T72783 WP_011447039.1 NZ_CP019594:c2014864-2014688 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T72783 NZ_CP019594:c2014864-2014688 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTACAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT72783 NZ_CP019594:2014557-2014696 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin