Detailed information of TA system TA072781

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 992229..992478
• Replicon: chromosome
• Accession: NZ_CP019594
• Organism: Staphylococcus aureus strain GD1539

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: BZK08_RS05000
• Protein ID: WP_000623369.1
• Coordinates: 992229..992336 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	992331..992478 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZK08_RS04975	988903..989472	-	570	WP_000287265.1	competence protein ComK	-
BZK08_RS04980	989682..989900	+	219	WP_000876826.1	IDEAL domain-containing protein	-
BZK08_RS04985	989981..990967	-	987	WP_000668814.1	lipoate--protein ligase	-
BZK08_RS04990	991166..991342	+	177	WP_000214898.1	YkvS family protein	-
BZK08_RS04995	991357..991959	+	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
BZK08_RS05000	992229..992336	+	108	WP_000623369.1	putative holin-like toxin	Toxin
-	992331..992478	-	148	-	-	Antitoxin
BZK08_RS05005	992971..993255	+	285	WP_000790905.1	lactococcin 972 family bacteriocin	-
BZK08_RS05010	993299..995263	+	1965	WP_000870811.1	bacteriocin-associated integral membrane family protein	-
BZK08_RS05015	995266..995586	+	321	WP_000668623.1	YxeA family protein	-
BZK08_RS05020	995583..996224	+	642	WP_000571192.1	ABC transporter ATP-binding protein	-
BZK08_RS05025	996312..996602	-	291	WP_001796515.1	hypothetical protein	-
BZK08_RS05030	996692..996880	+	189	WP_157958947.1	poly(glycerol-phosphate) alpha-glucosyltransferase	-
BZK08_RS05035	996969..997325	-	357	WP_000766009.1	DoxX family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T72781 WP_000623369.1 NZ_CP019594:992229-992336 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

>T72781 NZ_CP019594:992229-992336 [Staphylococcus aureus]
GTGATATCTATTGCAAATGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 148 bp

>AT72781 NZ_CP019594:c992478-992331 [Staphylococcus aureus]
CAATTAAATAAAAGATATGTTACTATAAAAATGTAAAAAGACGACATGCAGTAACATGTCGCCTAATGAGCCCGTTAAAA
AGACGGTGACTAAATGAGATTTGCTTTAACCATCATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Structures

Antitoxin