Detailed information of TA system TA072770

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1986751..1987050
• Replicon: chromosome
• Accession: NZ_CP019593
• Organism: Staphylococcus aureus strain GD705

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: BZK07_RS10125
• Protein ID: WP_072482930.1
• Coordinates: 1986874..1987050 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1986751..1986806 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZK07_RS10075	1982084..1982344	+	261	WP_001791826.1	hypothetical protein	-
BZK07_RS10080	1982397..1982747	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
BZK07_RS10085	1983430..1983879	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
BZK07_RS10090	1983974..1984308	-	335	Protein_1862	SH3 domain-containing protein	-
BZK07_RS10105	1984959..1985450	-	492	WP_000920042.1	staphylokinase	-
BZK07_RS10110	1985641..1986396	-	756	WP_000861040.1	CHAP domain-containing protein	-
BZK07_RS10115	1986408..1986662	-	255	WP_000611512.1	phage holin	-
BZK07_RS10120	1986714..1986821	+	108	Protein_1866	hypothetical protein	-
-	1986743..1986882	+	140	NuclAT_0	-	-
-	1986743..1986882	+	140	NuclAT_0	-	-
-	1986743..1986882	+	140	NuclAT_0	-	-
-	1986743..1986882	+	140	NuclAT_0	-	-
-	1986751..1986806	+	56	-	-	Antitoxin
BZK07_RS10125	1986874..1987050	-	177	WP_072482930.1	putative holin-like toxin	Toxin
BZK07_RS10130	1987159..1987932	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
BZK07_RS10135	1988305..1988679	-	375	WP_000340977.1	hypothetical protein	-
BZK07_RS10140	1988735..1989022	-	288	WP_001262621.1	hypothetical protein	-
BZK07_RS10145	1989068..1989220	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / sea / hlb / groEL	1982397..2034703	52306

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T72770 WP_072482930.1 NZ_CP019593:c1987050-1986874 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T72770 NZ_CP019593:c1987050-1986874 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT72770 NZ_CP019593:1986751-1986806 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin