Detailed information of TA system TA072765

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1524742..1525321
• Replicon: chromosome
• Accession: NZ_CP019593
• Organism: Staphylococcus aureus strain GD705

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: BZK07_RS07550
• Protein ID: WP_001025401.1
• Coordinates: 1525076..1525321 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1524742..1525107 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZK07_RS07500	1521022..1521579	-	558	WP_000645045.1	DUF2815 family protein	-
BZK07_RS07505	1521605..1522771	-	1167	WP_084570109.1	DUF2800 domain-containing protein	-
BZK07_RS07510	1522768..1523130	-	363	WP_084570110.1	hypothetical protein	-
BZK07_RS07515	1523145..1523468	-	324	WP_000174996.1	hypothetical protein	-
BZK07_RS07520	1523547..1523708	-	162	WP_084570111.1	DUF1270 family protein	-
BZK07_RS07525	1523721..1523984	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
BZK07_RS07530	1524039..1524248	+	210	WP_000642492.1	hypothetical protein	-
BZK07_RS07535	1524238..1524381	-	144	WP_000939498.1	hypothetical protein	-
BZK07_RS07540	1524472..1524687	-	216	WP_001097552.1	hypothetical protein	-
BZK07_RS07545	1524742..1525107	+	366	WP_001128433.1	hypothetical protein	Antitoxin
BZK07_RS07550	1525076..1525321	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
BZK07_RS07555	1525337..1525585	-	249	WP_031887139.1	helix-turn-helix domain-containing protein	-
BZK07_RS07560	1525749..1526072	+	324	WP_001260486.1	helix-turn-helix domain-containing protein	-
BZK07_RS07565	1526085..1526546	+	462	WP_084570112.1	toxin	-
BZK07_RS07570	1526564..1526998	+	435	WP_000755718.1	hypothetical protein	-
BZK07_RS07575	1527027..1527422	+	396	WP_084570113.1	hypothetical protein	-
BZK07_RS07580	1527512..1527658	+	147	WP_001013104.1	hypothetical protein	-
BZK07_RS07585	1527655..1528269	-	615	WP_084570114.1	ATPase	-
BZK07_RS07590	1528395..1529600	+	1206	WP_020444721.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T72765 WP_001025401.1 NZ_CP019593:c1525321-1525076 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T72765 NZ_CP019593:c1525321-1525076 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT72765 NZ_CP019593:1524742-1525107 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin