Detailed information of TA system TA072756

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 2028861..2029284
• Replicon: chromosome
• Accession: NZ_CP019592
• Organism: Staphylococcus aureus strain GD5

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BZJ79_RS10300
• Protein ID: WP_001836226.1
• Coordinates: 2029033..2029284 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BZJ79_RS10295
• Protein ID: WP_000028421.1
• Coordinates: 2028861..2029043 (-)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZJ79_RS10255	2025099..2025443	-	345	WP_000402904.1	hypothetical protein	-
BZJ79_RS10260	2025573..2025872	-	300	WP_000988330.1	HNH endonuclease	-
BZJ79_RS10265	2026104..2026520	-	417	WP_000590122.1	hypothetical protein	-
BZJ79_RS10270	2026548..2026748	-	201	WP_000265041.1	DUF1514 family protein	-
BZJ79_RS10275	2026748..2027398	-	651	WP_084578713.1	hypothetical protein	-
BZJ79_RS10280	2027557..2027706	-	150	WP_070030217.1	transcriptional regulator	-
BZJ79_RS10285	2027719..2028177	-	459	WP_031768021.1	hypothetical protein	-
BZJ79_RS14365	2028170..2028322	-	153	WP_031768020.1	DUF1381 domain-containing protein	-
BZJ79_RS10290	2028359..2028868	-	510	WP_031866561.1	dUTP pyrophosphatase	-
BZJ79_RS10295	2028861..2029043	-	183	WP_000028421.1	hypothetical protein	Antitoxin
BZJ79_RS10300	2029033..2029284	-	252	WP_001836226.1	DUF1024 family protein	Toxin
BZJ79_RS10305	2029277..2029648	-	372	WP_001616813.1	hypothetical protein	-
BZJ79_RS10310	2029657..2029899	-	243	WP_000131379.1	phi PVL orf 51-like protein	-
BZJ79_RS10315	2029903..2030271	-	369	WP_000101270.1	hypothetical protein	-
BZJ79_RS10320	2030284..2030688	-	405	WP_000401964.1	RusA family crossover junction endodeoxyribonuclease	-
BZJ79_RS10325	2030697..2030915	-	219	WP_053819389.1	hypothetical protein	-
BZJ79_RS10330	2030922..2031795	-	874	Protein_1892	DnaD domain protein	-
BZJ79_RS10335	2031825..2032295	-	471	WP_017466775.1	single-stranded DNA-binding protein	-
BZJ79_RS10340	2032296..2032913	-	618	WP_071621397.1	MBL fold metallo-hydrolase	-
BZJ79_RS10345	2032994..2033914	-	921	WP_000138475.1	recombinase RecT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2001628..2057039	55411

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9457.35 Da
• Isoelectric Point: 3.8049

>T72756 WP_001836226.1 NZ_CP019592:c2029284-2029033 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTGQVVYKYEEEQE
NEH

Nucleotide

• Length: 252 bp

>T72756 NZ_CP019592:c2029284-2029033 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATCGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAAGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGGGACAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6683.59 Da
• Isoelectric Point: 4.3791

>AT72756 WP_000028421.1 NZ_CP019592:c2029043-2028861 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND

Nucleotide

• Length: 183 bp

>AT72756 NZ_CP019592:c2029043-2028861 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA