Detailed information of TA system TA072754

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2005984..2006283
• Replicon: chromosome
• Accession: NZ_CP019592
• Organism: Staphylococcus aureus strain GD5

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: BZJ79_RS10160
• Protein ID: WP_011447039.1
• Coordinates: 2006107..2006283 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2005984..2006039 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZJ79_RS10105	2001315..2001575	+	261	WP_001791826.1	hypothetical protein	-
BZJ79_RS10110	2001628..2001978	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
BZJ79_RS10115	2002663..2003112	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
BZJ79_RS14360	2003207..2003542	-	336	Protein_1852	SH3 domain-containing protein	-
BZJ79_RS10140	2004192..2004683	-	492	WP_000919350.1	staphylokinase	-
BZJ79_RS10145	2004874..2005629	-	756	WP_000861038.1	CHAP domain-containing protein	-
BZJ79_RS10150	2005641..2005895	-	255	WP_000611512.1	phage holin	-
BZJ79_RS10155	2005947..2006054	+	108	WP_001791821.1	hypothetical protein	-
-	2005976..2006115	+	140	NuclAT_0	-	-
-	2005976..2006115	+	140	NuclAT_0	-	-
-	2005976..2006115	+	140	NuclAT_0	-	-
-	2005976..2006115	+	140	NuclAT_0	-	-
-	2005984..2006039	+	56	-	-	Antitoxin
BZJ79_RS10160	2006107..2006283	-	177	WP_011447039.1	putative holin-like toxin	Toxin
BZJ79_RS10165	2006433..2006729	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
BZJ79_RS10170	2006787..2007074	-	288	WP_084568217.1	hypothetical protein	-
BZJ79_RS10175	2007121..2007273	-	153	WP_001153681.1	hypothetical protein	-
BZJ79_RS10180	2007263..2011048	-	3786	WP_060555201.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2001628..2057039	55411

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T72754 WP_011447039.1 NZ_CP019592:c2006283-2006107 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T72754 NZ_CP019592:c2006283-2006107 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTACAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT72754 NZ_CP019592:2005984-2006039 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin