Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2117820..2118083 Replicon chromosome
Accession NZ_CP019591
Organism Staphylococcus aureus strain 293G

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag BXP64_RS10785 Protein ID WP_001802298.1
Coordinates 2117979..2118083 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2117820..2117984 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BXP64_RS10765 2114005..2114670 - 666 WP_001024099.1 SDR family oxidoreductase -
BXP64_RS10770 2114822..2115142 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
BXP64_RS10775 2115144..2116124 + 981 WP_000019735.1 CDF family zinc efflux transporter CzrB -
BXP64_RS10780 2116390..2117481 + 1092 WP_000495673.1 hypothetical protein -
- 2117820..2117984 + 165 - - Antitoxin
BXP64_RS10785 2117979..2118083 - 105 WP_001802298.1 hypothetical protein Toxin
BXP64_RS10800 2118763..2118921 + 159 WP_001792784.1 hypothetical protein -
BXP64_RS10805 2119357..2119449 + 93 WP_000220902.1 hypothetical protein -
BXP64_RS10810 2119579..2120436 - 858 WP_000370942.1 Cof-type HAD-IIB family hydrolase -
BXP64_RS10815 2120504..2121286 - 783 WP_000908191.1 ABC transporter ATP-binding protein -
BXP64_RS10820 2121576..2122184 - 609 WP_000101715.1 TIR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T72746 WP_001802298.1 NZ_CP019591:c2118083-2117979 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T72746 NZ_CP019591:c2118083-2117979 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT72746 NZ_CP019591:2117820-2117984 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References