Detailed information of TA system TA072732

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2271388..2271651
• Replicon: chromosome
• Accession: NZ_CP019590
• Organism: Staphylococcus aureus strain C2406

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: BJN19_RS11950
• Protein ID: WP_001802298.1
• Coordinates: 2271547..2271651 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2271388..2271552 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJN19_RS11930	2267574..2268239	-	666	WP_001024094.1	SDR family oxidoreductase	-
BJN19_RS11935	2268391..2268711	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
BJN19_RS11940	2268713..2269690	+	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
BJN19_RS11945	2269956..2271047	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2271388..2271552	+	165	-	-	Antitoxin
BJN19_RS11950	2271547..2271651	-	105	WP_001802298.1	hypothetical protein	Toxin
BJN19_RS15230	2271812..2272295	-	484	Protein_2204	recombinase family protein	-
BJN19_RS11960	2272338..2273474	-	1137	WP_000115564.1	SAP domain-containing protein	-
BJN19_RS11965	2273763..2273855	+	93	WP_001790138.1	hypothetical protein	-
BJN19_RS11970	2274560..2275417	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
BJN19_RS11975	2275485..2276267	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-99)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T72732 WP_001802298.1 NZ_CP019590:c2271651-2271547 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T72732 NZ_CP019590:c2271651-2271547 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT72732 NZ_CP019590:2271388-2271552 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin