Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2271388..2271651 Replicon chromosome
Accession NZ_CP019590
Organism Staphylococcus aureus strain C2406

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag BJN19_RS11950 Protein ID WP_001802298.1
Coordinates 2271547..2271651 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2271388..2271552 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJN19_RS11930 2267574..2268239 - 666 WP_001024094.1 SDR family oxidoreductase -
BJN19_RS11935 2268391..2268711 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
BJN19_RS11940 2268713..2269690 + 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
BJN19_RS11945 2269956..2271047 + 1092 WP_000495671.1 lytic regulatory protein -
- 2271388..2271552 + 165 - - Antitoxin
BJN19_RS11950 2271547..2271651 - 105 WP_001802298.1 hypothetical protein Toxin
BJN19_RS15230 2271812..2272295 - 484 Protein_2204 recombinase family protein -
BJN19_RS11960 2272338..2273474 - 1137 WP_000115564.1 SAP domain-containing protein -
BJN19_RS11965 2273763..2273855 + 93 WP_001790138.1 hypothetical protein -
BJN19_RS11970 2274560..2275417 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
BJN19_RS11975 2275485..2276267 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T72732 WP_001802298.1 NZ_CP019590:c2271651-2271547 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T72732 NZ_CP019590:c2271651-2271547 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT72732 NZ_CP019590:2271388-2271552 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References