Detailed information of TA system TA072726

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2096767..2097066
• Replicon: chromosome
• Accession: NZ_CP019590
• Organism: Staphylococcus aureus strain C2406

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: BJN19_RS10920
• Protein ID: WP_011447039.1
• Coordinates: 2096890..2097066 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2096767..2096822 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJN19_RS10865	2092098..2092358	+	261	WP_001791826.1	hypothetical protein	-
BJN19_RS10870	2092411..2092761	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
BJN19_RS10875	2093446..2093895	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
BJN19_RS15225	2093990..2094325	-	336	Protein_2005	SH3 domain-containing protein	-
BJN19_RS10900	2094975..2095466	-	492	WP_000919350.1	staphylokinase	-
BJN19_RS10905	2095657..2096412	-	756	WP_000861038.1	CHAP domain-containing protein	-
BJN19_RS10910	2096424..2096678	-	255	WP_000611512.1	phage holin	-
BJN19_RS10915	2096730..2096837	+	108	WP_001791821.1	hypothetical protein	-
-	2096759..2096898	+	140	NuclAT_0	-	-
-	2096759..2096898	+	140	NuclAT_0	-	-
-	2096759..2096898	+	140	NuclAT_0	-	-
-	2096759..2096898	+	140	NuclAT_0	-	-
-	2096767..2096822	+	56	-	-	Antitoxin
BJN19_RS10920	2096890..2097066	-	177	WP_011447039.1	putative holin-like toxin	Toxin
BJN19_RS10925	2097216..2097512	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
BJN19_RS10930	2097570..2097857	-	288	WP_001040261.1	hypothetical protein	-
BJN19_RS10935	2097904..2098056	-	153	WP_001153681.1	hypothetical protein	-
BJN19_RS10940	2098046..2101831	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb	2092411..2137411	45000

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T72726 WP_011447039.1 NZ_CP019590:c2097066-2096890 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T72726 NZ_CP019590:c2097066-2096890 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT72726 NZ_CP019590:2096767-2096822 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin