Detailed information of TA system TA072688

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1888122..1888304
• Replicon: chromosome
• Accession: NZ_CP019574
• Organism: Staphylococcus aureus strain USA400-0051

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: SAU400_RS14775
• Protein ID: WP_001801861.1
• Coordinates: 1888122..1888217 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1888245..1888304 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAU400_RS09490	1883793..1884419	+	627	WP_000669017.1	hypothetical protein	-
SAU400_RS09495	1884460..1884801	+	342	WP_000627541.1	DUF3969 family protein	-
SAU400_RS09500	1884902..1885474	+	573	WP_000414202.1	hypothetical protein	-
SAU400_RS09505	1885672..1886229	-	558	Protein_1782	ImmA/IrrE family metallo-endopeptidase	-
SAU400_RS09515	1886602..1886778	-	177	WP_000375477.1	hypothetical protein	-
SAU400_RS09520	1886789..1887172	-	384	WP_000070811.1	hypothetical protein	-
SAU400_RS09530	1887776..1887919	-	144	WP_001549059.1	transposase	-
SAU400_RS14775	1888122..1888217	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1888245..1888304	-	60	-	-	Antitoxin
SAU400_RS09540	1888340..1888441	+	102	WP_001791893.1	hypothetical protein	-
SAU400_RS09545	1888419..1888595	-	177	Protein_1788	transposase	-
SAU400_RS09550	1888789..1889166	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1882029..1938999	56970

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T72688 WP_001801861.1 NZ_CP019574:1888122-1888217 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T72688 NZ_CP019574:1888122-1888217 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT72688 NZ_CP019574:c1888304-1888245 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin