Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1447243..1447657 Replicon chromosome
Accession NZ_CP019563
Organism Staphylococcus aureus strain SR434

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BZP34_RS07670 Protein ID WP_077156080.1
Coordinates 1447406..1447657 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BZP34_RS15240 Protein ID WP_000028423.1
Coordinates 1447243..1447416 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZP34_RS07625 1442970..1444193 - 1224 WP_001037578.1 PBSX family phage terminase large subunit -
BZP34_RS07630 1444186..1444680 - 495 WP_000594088.1 terminase small subunit -
BZP34_RS07640 1445035..1445436 - 402 WP_000286968.1 hypothetical protein -
BZP34_RS07645 1445437..1445610 - 174 WP_076692344.1 transcriptional activator RinB -
BZP34_RS07650 1445610..1445996 - 387 WP_010924755.1 hypothetical protein -
BZP34_RS07655 1445986..1446222 - 237 WP_000608278.1 hypothetical protein -
BZP34_RS07660 1446215..1446502 - 288 WP_001613442.1 DUF1381 domain-containing protein -
BZP34_RS07665 1446539..1447066 - 528 WP_001061837.1 dUTPase -
BZP34_RS15235 1447081..1447242 - 162 WP_000889684.1 hypothetical protein -
BZP34_RS15240 1447243..1447416 - 174 WP_000028423.1 hypothetical protein Antitoxin
BZP34_RS07670 1447406..1447657 - 252 WP_077156080.1 DUF1024 family protein Toxin
BZP34_RS07675 1447650..1447934 - 285 WP_031807825.1 hypothetical protein -
BZP34_RS07680 1447931..1448368 - 438 WP_031807826.1 hypothetical protein -
BZP34_RS07685 1448365..1448559 - 195 WP_031794818.1 hypothetical protein -
BZP34_RS07690 1448556..1448957 - 402 WP_077156081.1 hypothetical protein -
BZP34_RS07695 1448972..1449220 - 249 WP_075339544.1 phi PVL orf 51-like protein -
BZP34_RS07700 1449229..1449429 - 201 WP_000235326.1 hypothetical protein -
BZP34_RS07705 1449432..1449659 - 228 WP_077156082.1 DUF3310 domain-containing protein -
BZP34_RS07710 1449665..1449733 - 69 Protein_1441 hypothetical protein -
BZP34_RS07715 1449734..1449922 - 189 WP_020808085.1 DUF3113 family protein -
BZP34_RS07720 1449927..1450331 - 405 WP_000049810.1 DUF1064 domain-containing protein -
BZP34_RS07725 1450341..1450562 - 222 WP_001123673.1 DUF3269 family protein -
BZP34_RS07730 1450575..1450733 - 159 WP_000256597.1 hypothetical protein -
BZP34_RS07735 1450727..1451506 - 780 WP_077156083.1 ATP-binding protein -
BZP34_RS07740 1451516..1452286 - 771 WP_077156084.1 conserved phage C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1418224..1461240 43016


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9363.24 Da        Isoelectric Point: 3.9473

>T72668 WP_077156080.1 NZ_CP019563:c1447657-1447406 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T72668 NZ_CP019563:c1447657-1447406 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6482.32 Da        Isoelectric Point: 4.2484

>AT72668 WP_000028423.1 NZ_CP019563:c1447416-1447243 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSIISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT72668 NZ_CP019563:c1447416-1447243 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAATTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References