Detailed information of TA system TA072663

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 59286..59624
• Replicon: chromosome
• Accession: NZ_CP019563
• Organism: Staphylococcus aureus strain SR434

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: BZP34_RS00380
• Protein ID: WP_011447039.1
• Coordinates: 59286..59462 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	59450..59624 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZP34_RS00360	56979..57131	+	153	WP_001000058.1	hypothetical protein	-
BZP34_RS00365	57177..57464	+	288	WP_031865201.1	hypothetical protein	-
BZP34_RS00370	57520..57894	+	375	WP_000340977.1	hypothetical protein	-
BZP34_RS00375	58310..59083	+	774	WP_025174055.1	staphylococcal enterotoxin type P	-
BZP34_RS00380	59286..59462	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	59450..59624	-	175	-	-	Antitoxin
BZP34_RS00390	59674..59928	+	255	WP_000611512.1	phage holin	-
BZP34_RS00395	59940..60695	+	756	WP_000861026.1	CHAP domain-containing protein	-
BZP34_RS00400	60886..61377	+	492	WP_000920042.1	staphylokinase	-
BZP34_RS00415	62028..62362	+	335	Protein_82	SH3 domain-containing protein	-
BZP34_RS00420	62457..62906	-	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
BZP34_RS00425	63589..63939	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
BZP34_RS00430	63992..64252	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	tsst-1 / sec / sell / hlb / see / sak / chp / scn	34..63939	63905

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T72663 WP_011447039.1 NZ_CP019563:59286-59462 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T72663 NZ_CP019563:59286-59462 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT72663 NZ_CP019563:c59624-59450 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin