Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 452758..453406 Replicon chromosome
Accession NZ_CP019562
Organism Streptococcus oralis strain S.MIT/ORALIS-351

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BWR56_RS02145 Protein ID WP_076984365.1
Coordinates 452758..453123 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BWR56_RS02150 Protein ID WP_076984366.1
Coordinates 453113..453406 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWR56_RS02120 448737..450125 + 1389 WP_076984360.1 hypothetical protein -
BWR56_RS02125 450302..450640 + 339 WP_076984361.1 type II toxin-antitoxin system RelE/ParE family toxin -
BWR56_RS02130 450633..451718 + 1086 WP_076984362.1 HigA family addiction module antidote protein -
BWR56_RS02135 451848..452252 + 405 WP_076984363.1 YbgA family protein -
BWR56_RS02140 452236..452601 + 366 WP_076984364.1 TIGR02328 family protein -
BWR56_RS02145 452758..453123 + 366 WP_076984365.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWR56_RS02150 453113..453406 + 294 WP_076984366.1 helix-turn-helix transcriptional regulator Antitoxin
BWR56_RS02155 453759..456008 + 2250 WP_076984367.1 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
BWR56_RS02160 456069..456935 + 867 WP_049504734.1 methylenetetrahydrofolate reductase [NAD(P)H] -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 447658..461783 14125


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14577.77 Da        Isoelectric Point: 9.7913

>T72661 WP_076984365.1 NZ_CP019562:452758-453123 [Streptococcus oralis]
VHTIYFYKDKNGNEPVLDYMRELARKKSKDSRIKLNKLNDYIELLSQHGTRAGELYIKHLEDEIWELRPLRDRILFVAWL
DGSFVLLHHFVKKTQKTPRREIDKAKRELKDLKERGLSDEE

Download         Length: 366 bp

>T72661 NZ_CP019562:452758-453123 [Streptococcus oralis]
GTGCATACAATTTACTTCTATAAGGACAAAAATGGAAATGAGCCAGTCTTAGATTATATGAGAGAATTGGCTAGAAAGAA
GAGTAAGGATAGTCGCATCAAACTCAATAAACTAAACGACTATATCGAGTTGCTTAGTCAGCATGGGACTAGAGCTGGTG
AACTCTATATCAAACATTTGGAAGATGAGATTTGGGAACTAAGACCTCTGAGGGATAGGATTTTATTTGTAGCGTGGCTT
GATGGGAGTTTTGTTCTCTTACATCATTTTGTCAAAAAGACTCAGAAAACTCCTAGGAGAGAGATTGATAAAGCCAAGCG
TGAACTGAAGGACTTAAAAGAAAGAGGGTTAAGTGATGAAGAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10765.41 Da        Isoelectric Point: 5.1991

>AT72661 WP_076984366.1 NZ_CP019562:453113-453406 [Streptococcus oralis]
MKNSAIGSNWKDVRSELFTKEEILESDMRVAIMSELIEARHEQGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEQEKN

Download         Length: 294 bp

>AT72661 NZ_CP019562:453113-453406 [Streptococcus oralis]
ATGAAGAATAGTGCTATTGGGAGTAATTGGAAAGATGTCCGCTCTGAACTCTTCACCAAGGAGGAAATCCTTGAAAGTGA
TATGCGAGTGGCTATCATGAGTGAGTTGATTGAAGCCAGACACGAGCAAGGTATCAGTCAGAAAAAGCTAGAGGAACTCA
GTGGAGTGAGCCAGCCTGTCATAGCTAGGATGGAGACAGGAAAGACTAGTCCTCAGTTGGATACGGTCTTAAAAGTCTTA
GCCAGTTTAGGAAAGACACTAGCAGTCGTCCCACTTGAACAGGAAAAAAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References