Detailed information of TA system TA072608

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2992953..2993290
• Replicon: chromosome
• Accession: NZ_CP019512
• Organism: Enterococcus faecalis strain CLB21560

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: BZG32_RS15620
• Protein ID: WP_002396786.1
• Coordinates: 2992953..2993096 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2993028..2993290 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZG32_RS15590	2988230..2989525	-	1296	WP_002396787.1	AAA family ATPase	-
BZG32_RS15600	2989987..2991603	+	1617	WP_002358967.1	phosphatase PAP2/LCP family protein	-
BZG32_RS15605	2991958..2992080	+	123	WP_002404776.1	putative holin-like toxin	-
BZG32_RS15610	2992266..2992463	+	198	WP_002358966.1	putative holin-like toxin	-
BZG32_RS15615	2992582..2992722	+	141	WP_077143780.1	putative holin-like toxin	-
BZG32_RS15620	2992953..2993096	+	144	WP_002396786.1	putative holin-like toxin	Toxin
-	2993028..2993290	-	263	-	-	Antitoxin
BZG32_RS15625	2993291..2997982	-	4692	WP_002404775.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T72608 WP_002396786.1 NZ_CP019512:2992953-2993096 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T72608 NZ_CP019512:2992953-2993096 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT72608 NZ_CP019512:c2993290-2993028 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin