Detailed information of TA system TA072602

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2992582..2992856
• Replicon: chromosome
• Accession: NZ_CP019512
• Organism: Enterococcus faecalis strain CLB21560

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: BZG32_RS15615
• Protein ID: WP_077143780.1
• Coordinates: 2992582..2992722 (+)
• Length: 47 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2992655..2992856 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZG32_RS15585	2987589..2988221	-	633	WP_002358972.1	RloB family protein	-
BZG32_RS15590	2988230..2989525	-	1296	WP_002396787.1	AAA family ATPase	-
BZG32_RS15600	2989987..2991603	+	1617	WP_002358967.1	phosphatase PAP2/LCP family protein	-
BZG32_RS15605	2991958..2992080	+	123	WP_002404776.1	putative holin-like toxin	-
BZG32_RS15610	2992266..2992463	+	198	WP_002358966.1	putative holin-like toxin	-
BZG32_RS15615	2992582..2992722	+	141	WP_077143780.1	putative holin-like toxin	Toxin
-	2992655..2992856	-	202	-	-	Antitoxin
BZG32_RS15620	2992953..2993096	+	144	WP_002396786.1	putative holin-like toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-46)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5188.30 Da
• Isoelectric Point: 10.3265

>T72602 WP_077143780.1 NZ_CP019512:2992582-2992722 [Enterococcus faecalis]
ISLKNTNKNIVYCTAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 141 bp

>T72602 NZ_CP019512:2992582-2992722 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 202 bp

>AT72602 NZ_CP019512:c2992856-2992655 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTGTAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin