Detailed information of TA system TA072582

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2914516..2914776
• Replicon: chromosome
• Accession: NZ_CP019512
• Organism: Enterococcus faecalis strain CLB21560

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: BZG32_RS15230
• Protein ID: WP_156194032.1
• Coordinates: 2914633..2914776 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2914516..2914700 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZG32_RS15215	2910077..2910790	-	714	WP_002354877.1	trehalose operon repressor	-
BZG32_RS15220	2911052..2913796	+	2745	WP_002404790.1	glycoside hydrolase family 65 protein	-
BZG32_RS15225	2913811..2914461	+	651	WP_002359015.1	beta-phosphoglucomutase	-
-	2914516..2914700	+	185	-	-	Antitoxin
BZG32_RS15230	2914633..2914776	-	144	WP_156194032.1	putative holin-like toxin	Toxin
BZG32_RS15235	2915007..2915978	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
BZG32_RS15240	2916153..2916590	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
BZG32_RS15245	2916723..2917277	-	555	WP_002359011.1	septum formation protein Maf	-
BZG32_RS15250	2917302..2919434	-	2133	WP_002359010.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5327.50 Da
• Isoelectric Point: 10.8331

>T72582 WP_156194032.1 NZ_CP019512:c2914776-2914633 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTISLIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

>T72582 NZ_CP019512:c2914776-2914633 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTTCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 185 bp

>AT72582 NZ_CP019512:2914516-2914700 [Enterococcus faecalis]
TGCTAGAATGTAGATGAAAAGAGAGAGATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTGAGACGGTGACCAATTGT
ATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGAAATGGTAAACATACCAA

Structures

Antitoxin