72551

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 72304..72838 Replicon plasmid pSym
Accession NZ_CP019487
Organism Sinorhizobium meliloti strain B399

Toxin (Protein)


Gene name parE Uniprot ID H0FXJ9
Locus tag BWO90_RS06480 Protein ID WP_003527848.1
Coordinates 72542..72838 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag BWO90_RS06475 Protein ID WP_095919241.1
Coordinates 72304..72552 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWO90_RS06440 67491..68534 + 1044 WP_010974980.1 iron ABC transporter permease -
BWO90_RS06445 68531..69331 + 801 WP_095919238.1 ABC transporter ATP-binding protein -
BWO90_RS06450 69335..70114 + 780 WP_095919240.1 methyltransferase domain-containing protein -
BWO90_RS06455 70206..71402 + 1197 WP_010969783.1 IS256-like element ISRm5 family transposase -
BWO90_RS06460 71561..71686 - 126 Protein_60 IS481 family transposase -
BWO90_RS06475 72304..72552 + 249 WP_095919241.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BWO90_RS06480 72542..72838 + 297 WP_003527848.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWO90_RS06485 72914..73177 - 264 Protein_63 helix-turn-helix domain-containing protein -
BWO90_RS06490 73759..74157 + 399 WP_010974988.1 hypothetical protein -
BWO90_RS06495 74324..74509 + 186 WP_014527652.1 hypothetical protein -
BWO90_RS06500 74513..74959 - 447 WP_014527651.1 DNA-binding protein -
BWO90_RS06505 75249..75458 + 210 WP_003527838.1 dodecin family protein -
BWO90_RS06510 75992..77371 + 1380 WP_027991363.1 sodium:alanine symporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1573992 1573992


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-93)

Antitoxin

Antitoxin ParD

(3-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11463.13 Da        Isoelectric Point: 10.6593

>T72551 WP_003527848.1 NZ_CP019487:72542-72838 [Sinorhizobium meliloti]
MATERPFRLAPAAKADLRKIWRYTARRWSLEQAETYQDQLYTAFEGLAAGTKKGRNVDVRPGYLKYPAGSHIVYFRDRGD
RIDIIRILHGRMDAQRHL

Download         Length: 297 bp

>T72551 NZ_CP019487:72542-72838 [Sinorhizobium meliloti]
ATGGCGACTGAACGGCCTTTCCGGCTCGCTCCTGCCGCCAAGGCCGACCTTCGGAAGATATGGCGCTACACGGCTCGCCG
CTGGTCTCTGGAACAGGCGGAGACCTACCAAGACCAGCTTTATACTGCATTTGAGGGACTGGCCGCAGGGACGAAGAAAG
GCCGCAATGTCGATGTGCGACCGGGTTATCTCAAATACCCGGCAGGATCGCACATCGTCTATTTTCGGGATCGCGGCGAC
CGGATCGACATCATCCGCATCCTGCATGGCCGGATGGATGCCCAACGGCATTTGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8957.83 Da        Isoelectric Point: 4.3239

>AT72551 WP_095919241.1 NZ_CP019487:72304-72552 [Sinorhizobium meliloti]
MAARSTSISLGDHFAGFIDRQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD

Download         Length: 249 bp

>AT72551 NZ_CP019487:72304-72552 [Sinorhizobium meliloti]
ATGGCTGCTAGAAGCACATCTATTTCCCTTGGCGATCACTTCGCCGGTTTCATCGACCGCCAGGTGCAAACCGGCCGCTA
CGGCTCCGCCAGCGACGTTGTGCGGGCTGGACTTCGGCTTTTGGAAGAACACGAGGCGAAGGTAAGGGCGCTGGAAGCGG
CTTTGATCGAGGGCGAAGAATCCGGCGAGCCAGAGCCATTCGACAACGAAGCGTTCAAAGCCGAAATGCGCGCCGAATAT
GGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0FXJ9

Antitoxin

Source ID Structure

References