Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 284519..285053 Replicon plasmid pSymB
Accession NZ_CP019484
Organism Sinorhizobium meliloti strain B401

Toxin (Protein)


Gene name parE Uniprot ID H0FXJ9
Locus tag BWO76_RS07310 Protein ID WP_003527848.1
Coordinates 284757..285053 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag BWO76_RS07305 Protein ID WP_095919241.1
Coordinates 284519..284767 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWO76_RS07270 279972..281057 + 1086 WP_095926547.1 ABC transporter substrate-binding protein -
BWO76_RS07275 281054..282097 + 1044 WP_010974980.1 iron ABC transporter permease -
BWO76_RS07280 282094..282894 + 801 WP_095919238.1 ABC transporter ATP-binding protein -
BWO76_RS07285 282898..283692 + 795 WP_013850206.1 methyltransferase domain-containing protein -
BWO76_RS07290 283776..283901 - 126 Protein_252 IS481 family transposase -
BWO76_RS07305 284519..284767 + 249 WP_095919241.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BWO76_RS07310 284757..285053 + 297 WP_003527848.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWO76_RS07315 285124..285387 - 264 Protein_255 helix-turn-helix domain-containing protein -
BWO76_RS07320 285961..286359 + 399 WP_010974988.1 hypothetical protein -
BWO76_RS07325 286526..286711 + 186 WP_014527652.1 hypothetical protein -
BWO76_RS07330 286715..287161 - 447 WP_014527651.1 DNA-binding protein -
BWO76_RS07335 287451..287660 + 210 WP_003527838.1 dodecin family protein -
BWO76_RS07340 288194..289573 + 1380 WP_027991363.1 sodium:alanine symporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1584717 1584717
- flank IS/Tn - - 283776..283967 191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-93)

Antitoxin

Antitoxin ParD

(3-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11463.13 Da        Isoelectric Point: 10.6593

>T72536 WP_003527848.1 NZ_CP019484:284757-285053 [Sinorhizobium meliloti]
MATERPFRLAPAAKADLRKIWRYTARRWSLEQAETYQDQLYTAFEGLAAGTKKGRNVDVRPGYLKYPAGSHIVYFRDRGD
RIDIIRILHGRMDAQRHL

Download         Length: 297 bp

>T72536 NZ_CP019484:284757-285053 [Sinorhizobium meliloti]
ATGGCGACTGAACGGCCTTTCCGGCTCGCTCCTGCCGCCAAGGCCGACCTTCGGAAGATATGGCGCTACACGGCTCGCCG
CTGGTCTCTGGAACAGGCGGAGACCTACCAAGACCAGCTTTATACTGCATTTGAGGGACTGGCCGCAGGGACGAAGAAAG
GCCGCAATGTCGATGTGCGACCGGGTTATCTCAAATACCCGGCAGGATCGCACATCGTCTATTTTCGGGATCGCGGCGAC
CGGATCGACATCATCCGCATCCTGCATGGCCGGATGGATGCCCAACGGCATTTGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8957.83 Da        Isoelectric Point: 4.3239

>AT72536 WP_095919241.1 NZ_CP019484:284519-284767 [Sinorhizobium meliloti]
MAARSTSISLGDHFAGFIDRQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD

Download         Length: 249 bp

>AT72536 NZ_CP019484:284519-284767 [Sinorhizobium meliloti]
ATGGCTGCTAGAAGCACATCTATTTCCCTTGGCGATCACTTCGCCGGTTTCATCGACCGCCAGGTGCAAACCGGCCGCTA
CGGCTCCGCCAGCGACGTTGTGCGGGCTGGACTTCGGCTTTTGGAAGAACACGAGGCGAAGGTAAGGGCGCTGGAAGCGG
CTTTGATCGAGGGCGAAGAATCCGGCGAGCCAGAGCCATTCGACAACGAAGCGTTCAAAGCCGAAATGCGCGCCGAATAT
GGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0FXJ9

Antitoxin

Source ID Structure

References