Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2686362..2686620 Replicon chromosome
Accession NZ_CP019455
Organism Escherichia coli strain FHI_NMBU_03

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag BXO92_RS13460 Protein ID WP_000809168.1
Coordinates 2686362..2686514 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 2686563..2686620 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BXO92_RS13440 2681607..2682320 - 714 WP_001102393.1 acidic protein MsyB -
BXO92_RS13445 2682346..2682750 - 405 WP_000843689.1 DUF2541 family protein -
BXO92_RS13450 2683122..2685038 + 1917 WP_000516135.1 molecular chaperone DnaK -
BXO92_RS13455 2685127..2686257 + 1131 WP_001118464.1 molecular chaperone DnaJ -
BXO92_RS13460 2686362..2686514 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 2686563..2686620 + 58 - - Antitoxin
BXO92_RS13470 2687129..2687890 + 762 WP_001274832.1 hypothetical protein -
BXO92_RS13475 2687911..2689404 + 1494 WP_024223387.1 sulfatase-like hydrolase/transferase -
BXO92_RS13480 2689533..2690792 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T72487 WP_000809168.1 NZ_CP019455:c2686514-2686362 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T72487 NZ_CP019455:c2686514-2686362 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT72487 NZ_CP019455:2686563-2686620 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References