Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 46650..47491 Replicon plasmid unnamed2
Accession NZ_CP019439
Organism Thioclava nitratireducens strain 25B10_4

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag BMG03_RS20200 Protein ID WP_075777221.1
Coordinates 46973..47491 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag BMG03_RS20195 Protein ID WP_075777243.1
Coordinates 46650..46976 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMG03_RS20170 42273..42482 + 210 WP_075777226.1 hypothetical protein -
BMG03_RS20175 42570..42959 + 390 WP_075777225.1 DUF3768 domain-containing protein -
BMG03_RS20180 43117..45099 + 1983 WP_075777224.1 ParB/RepB/Spo0J family partition protein -
BMG03_RS20185 45176..45769 + 594 WP_075777223.1 regulator -
BMG03_RS20190 45872..46525 + 654 WP_075777222.1 hypothetical protein -
BMG03_RS20195 46650..46976 + 327 WP_075777243.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
BMG03_RS20200 46973..47491 + 519 WP_075777221.1 type II toxin-antitoxin system YhaV family toxin Toxin
BMG03_RS20205 47639..47791 + 153 WP_075777220.1 StaA -
BMG03_RS20210 47894..52156 + 4263 WP_075777219.1 strawberry notch family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..114001 114001


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(19-155)

Antitoxin

PrlF antitoxin

(9-104)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19168.80 Da        Isoelectric Point: 9.3138

>T72453 WP_075777221.1 NZ_CP019439:46973-47491 [Thioclava nitratireducens]
MSGDSVPAGAPLVVNGWSIYAHPLFLDQLEGLILEVEARKARDPKTWCKKNSAKRLAAIFKLVTEAIPADPGAAAFRQGG
TLGDHRKHWFRAKFFQQYRLFYRFNSDAKVIVVAWVNDDKTLRAYGSKTDAYATFKGMLEDGNPPENFDALLKEAAAADK
RFETSLEAATDR

Download         Length: 519 bp

>T72453 NZ_CP019439:46973-47491 [Thioclava nitratireducens]
ATGAGCGGCGATAGCGTGCCCGCAGGGGCGCCCCTTGTCGTAAACGGATGGTCGATTTATGCGCATCCGCTCTTTCTGGA
CCAGCTCGAAGGGCTGATCCTGGAGGTCGAGGCGCGTAAGGCTCGCGATCCAAAGACCTGGTGCAAGAAAAATTCCGCGA
AACGGCTGGCCGCCATCTTCAAGCTGGTGACCGAGGCCATACCGGCGGACCCGGGTGCCGCCGCCTTCCGGCAAGGCGGC
ACACTCGGCGATCACCGCAAGCACTGGTTCCGGGCGAAATTCTTCCAGCAGTATCGGCTGTTCTACCGGTTCAACAGCGA
TGCAAAGGTCATCGTGGTGGCCTGGGTGAACGACGACAAGACCCTGCGCGCCTATGGCAGCAAGACGGATGCCTACGCGA
CGTTCAAAGGGATGCTGGAAGATGGCAACCCACCTGAAAATTTTGACGCGCTCTTGAAAGAAGCGGCGGCGGCGGACAAG
CGGTTCGAGACGTCTCTTGAAGCGGCGACCGATCGGTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11908.35 Da        Isoelectric Point: 4.3118

>AT72453 WP_075777243.1 NZ_CP019439:46650-46976 [Thioclava nitratireducens]
MTVLTQDVSKLTDRYQTTVPAGVRKQLKLGKGDQIRYCTEPSGRVYIEPVRAEEDDPALGAFLDFVEADIKAHPDRIRAF
DGALHDRLAALVGDVDVDLDAPLSPEDE

Download         Length: 327 bp

>AT72453 NZ_CP019439:46650-46976 [Thioclava nitratireducens]
ATGACAGTGCTCACACAAGATGTCTCGAAGCTCACGGATCGGTATCAGACAACCGTGCCGGCAGGTGTGCGAAAGCAGCT
CAAGCTGGGCAAGGGCGACCAGATTCGCTACTGCACCGAGCCGAGTGGCAGGGTCTATATCGAGCCCGTGCGCGCCGAAG
AGGATGATCCCGCGCTCGGCGCCTTTCTCGATTTTGTCGAGGCAGATATCAAGGCGCATCCGGACCGCATTCGGGCGTTC
GATGGGGCTTTGCATGACCGTCTTGCAGCACTGGTCGGAGACGTTGACGTCGATCTCGATGCGCCGCTATCGCCCGAGGA
TGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References