72440

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1688916..1689571 Replicon chromosome
Accession NZ_CP019431
Organism Pseudomonas sp. S35

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PspS35_RS07570 Protein ID WP_159933397.1
Coordinates 1688916..1689260 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PspS35_RS07575 Protein ID WP_159933398.1
Coordinates 1689257..1689571 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PspS35_RS07540 1684399..1685040 + 642 WP_159933391.1 LysE family translocator -
PspS35_RS07545 1685160..1685687 + 528 WP_159933392.1 DUF4142 domain-containing protein -
PspS35_RS07550 1685751..1686251 - 501 WP_159933393.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
PspS35_RS07555 1686352..1686684 - 333 WP_159933394.1 hypothetical protein -
PspS35_RS07560 1686773..1687303 - 531 WP_159933395.1 LysR family substrate-binding domain-containing protein -
PspS35_RS07565 1687399..1688556 + 1158 WP_159933396.1 MFS transporter -
PspS35_RS07570 1688916..1689260 + 345 WP_159933397.1 toxin Toxin
PspS35_RS07575 1689257..1689571 + 315 WP_159933398.1 transcriptional regulator Antitoxin
PspS35_RS07580 1689623..1690405 - 783 WP_159933399.1 hypothetical protein -
PspS35_RS07590 1690693..1691604 - 912 WP_159933401.1 integrase arm-type DNA-binding domain-containing protein -
PspS35_RS07600 1692187..1693071 - 885 WP_159933402.1 alpha/beta hydrolase -
PspS35_RS07605 1693377..1694069 - 693 WP_159937999.1 pseudouridine synthase -
PspS35_RS07610 1694059..1694271 - 213 WP_159933403.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(45-94)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13220.06 Da        Isoelectric Point: 9.5899

>T72440 WP_159933397.1 NZ_CP019431:1688916-1689260 [Pseudomonas sp. S35]
MKTVFFETTSFTATVGDYLTDDEYRQLQTEMQANPEAGDVMPRTGGFRKLRWQDVRRGKGKRGGLRVIYYWLMNYGQFWM
FAIYDKDEMGNLTADQEKALKAAIDAELKKRGGK

Download         Length: 345 bp

>T72440 NZ_CP019431:1688916-1689260 [Pseudomonas sp. S35]
ATGAAAACGGTCTTCTTCGAAACCACAAGCTTCACCGCCACGGTTGGTGACTACCTGACTGACGATGAGTATCGCCAGCT
TCAGACCGAAATGCAGGCGAATCCTGAGGCTGGCGATGTGATGCCACGTACCGGAGGCTTCAGAAAGCTCCGCTGGCAGG
ACGTTCGCCGAGGCAAGGGAAAGCGTGGTGGGCTGCGTGTCATTTACTACTGGCTGATGAATTACGGTCAGTTTTGGATG
TTTGCGATCTACGACAAGGATGAAATGGGGAACCTGACAGCTGATCAGGAGAAAGCACTGAAAGCTGCGATTGATGCAGA
GCTGAAAAAACGAGGTGGAAAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11912.87 Da        Isoelectric Point: 9.7649

>AT72440 WP_159933398.1 NZ_CP019431:1689257-1689571 [Pseudomonas sp. S35]
MKKRDLFTELMQGVGEMAEHRQGKITLRQYEVEALAPPEVTAAEIIAIREKLHMSQPVFARQIRTSPDTLKNWEQSKSKP
NAQAALLIKLVERFPDMVERLNAV

Download         Length: 315 bp

>AT72440 NZ_CP019431:1689257-1689571 [Pseudomonas sp. S35]
ATGAAAAAGCGCGATCTGTTTACAGAACTGATGCAGGGTGTTGGCGAGATGGCTGAACACCGGCAAGGGAAGATTACGCT
TCGCCAGTACGAAGTGGAGGCCCTTGCGCCCCCAGAGGTGACGGCTGCTGAGATCATTGCCATCCGTGAAAAACTGCACA
TGTCACAGCCCGTATTCGCCCGGCAGATCAGGACCAGTCCTGACACGCTGAAAAACTGGGAACAGTCTAAGTCCAAGCCC
AACGCTCAGGCGGCGCTGTTGATCAAGCTGGTTGAGCGCTTCCCGGATATGGTTGAGCGGCTGAACGCGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References