72432

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1876161..1876768 Replicon chromosome
Accession NZ_CP019428
Organism Pseudomonas sp. R76

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PspR76_RS08510 Protein ID WP_159954795.1
Coordinates 1876161..1876475 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PspR76_RS08515 Protein ID WP_159954796.1
Coordinates 1876475..1876768 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PspR76_RS08480 1871255..1871755 - 501 WP_159954790.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
PspR76_RS08485 1871845..1872255 - 411 WP_159954791.1 type II toxin-antitoxin system HicB family antitoxin -
PspR76_RS08490 1872279..1872461 - 183 WP_017736377.1 type II toxin-antitoxin system HicA family toxin -
PspR76_RS08495 1872629..1873522 - 894 WP_159954792.1 LysR family transcriptional regulator -
PspR76_RS08500 1873618..1874781 + 1164 WP_159954793.1 MFS transporter -
PspR76_RS08505 1874778..1875971 + 1194 WP_159954794.1 MFS transporter -
PspR76_RS08510 1876161..1876475 + 315 WP_159954795.1 hypothetical protein Toxin
PspR76_RS08515 1876475..1876768 + 294 WP_159954796.1 helix-turn-helix domain-containing protein Antitoxin
PspR76_RS08520 1876803..1877108 - 306 WP_159954797.1 metal ABC transporter ATPase -
PspR76_RS08525 1877132..1877656 - 525 WP_159954798.1 DUF3833 domain-containing protein -
PspR76_RS08535 1878121..1879005 - 885 WP_159954799.1 alpha/beta hydrolase -
PspR76_RS08540 1879310..1880002 - 693 WP_159954800.1 pseudouridine synthase -
PspR76_RS08545 1880002..1880214 - 213 WP_159954801.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11877.65 Da        Isoelectric Point: 8.4340

>T72432 WP_159954795.1 NZ_CP019428:1876161-1876475 [Pseudomonas sp. R76]
MIFIESLAFTEDLAALLSEESYGEFQAFLAENPTAGDVIQGTHGLRKIRWAVQGTGKSGGVRVIYYHLRMGYQIRLILIY
RKGVKDDLSTAEKRILSEINRRWE

Download         Length: 315 bp

>T72432 NZ_CP019428:1876161-1876475 [Pseudomonas sp. R76]
ATGATATTTATCGAGTCACTCGCATTTACAGAAGACTTGGCTGCGCTTCTAAGTGAGGAAAGCTACGGTGAGTTCCAAGC
ATTTCTGGCCGAAAATCCAACTGCCGGTGATGTCATACAGGGCACCCATGGTCTGAGGAAGATTCGCTGGGCTGTGCAGG
GTACGGGAAAGAGTGGTGGTGTCAGAGTGATCTATTACCACCTCCGTATGGGATATCAAATTAGATTGATCCTGATCTAT
CGAAAGGGTGTCAAAGATGACCTTTCGACGGCGGAAAAAAGAATCCTGAGTGAAATAAACCGAAGGTGGGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11082.73 Da        Isoelectric Point: 9.9175

>AT72432 WP_159954796.1 NZ_CP019428:1876475-1876768 [Pseudomonas sp. R76]
MEKKLFNRLVESMTQMDEIVRGERPPSREFFVDALKVKEIRQATGLSQARFAKAIDVPVGTLQNWEQGRREPEGPARALL
RALYNDPGHVLAALEHR

Download         Length: 294 bp

>AT72432 NZ_CP019428:1876475-1876768 [Pseudomonas sp. R76]
ATGGAGAAAAAACTGTTCAATCGTCTGGTCGAGAGCATGACCCAAATGGACGAAATTGTTCGGGGTGAGCGCCCACCATC
CCGTGAGTTTTTTGTTGATGCCTTGAAGGTCAAAGAGATTCGACAGGCTACGGGACTGTCACAAGCACGCTTTGCGAAGG
CAATTGATGTGCCTGTGGGAACGCTTCAAAACTGGGAGCAAGGGCGGCGTGAGCCAGAGGGGCCGGCAAGGGCGTTATTG
CGCGCTCTATACAATGATCCGGGCCACGTATTGGCAGCCTTGGAGCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References