Detailed information of TA system TA072416

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3569712..3570274
• Replicon: chromosome
• Accession: NZ_CP019400
• Organism: Acidipropionibacterium acidipropionici strain WSH1105

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BWX38_RS16330
• Protein ID: WP_076692624.1
• Coordinates: 3570041..3570274 (-)
• Length: 78 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: BWX38_RS16325
• Protein ID: WP_015069931.1
• Coordinates: 3569712..3570017 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWX38_RS16305	3565851..3567143	-	1293	WP_076692623.1	threonine/serine exporter family protein	-
BWX38_RS16310	3567151..3567969	-	819	WP_028701670.1	Nif3-like dinuclear metal center hexameric protein	-
BWX38_RS16315	3568094..3569110	+	1017	WP_015069930.1	YdcF family protein	-
BWX38_RS16325	3569712..3570017	-	306	WP_015069931.1	HigA family addiction module antidote protein	Antitoxin
BWX38_RS16330	3570041..3570274	-	234	WP_076692624.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BWX38_RS16335	3570330..3571751	-	1422	WP_015069932.1	type I glutamate--ammonia ligase	-
BWX38_RS16340	3571964..3573253	+	1290	WP_015069933.1	hypothetical protein	-
BWX38_RS16345	3573385..3573711	+	327	WP_148279616.1	RDD family protein	-
BWX38_RS16350	3573716..3574849	+	1134	WP_015069935.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (19-77)

Antitoxin

• Cro/C1-type helix-turn-helix domain (25-72)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8578.58 Da
• Isoelectric Point: 6.6970

>T72416 WP_076692624.1 NZ_CP019400:c3570274-3570041 [Acidipropionibacterium acidipropionici]
IIRPCCQHFTNGSTGGLVRLLNAASELNSPRVPPGNRLEKLVGGRDGQHSIRINDQYRICFVWTDNGADDVEITDYH

Nucleotide

• Length: 234 bp

>T72416 NZ_CP019400:c3570274-3570041 [Acidipropionibacterium acidipropionici]
ATCATCCGCCCGTGCTGCCAGCACTTCACCAACGGCAGCACGGGCGGACTCGTTCGCCTCCTCAACGCGGCCTCAGAACT
GAACAGCCCTCGGGTGCCGCCGGGAAATCGCTTGGAGAAGCTGGTCGGCGGCCGCGACGGCCAGCACTCCATCCGCATCA
ACGACCAGTACCGAATCTGCTTCGTGTGGACCGACAACGGAGCAGACGACGTCGAGATCACCGACTATCACTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11168.69 Da
• Isoelectric Point: 4.8182

>AT72416 WP_015069931.1 NZ_CP019400:c3570017-3569712 [Acidipropionibacterium acidipropionici]
MATASKAHDPITPGEILLTEFLEPMGITQYRLAQATGLSQTRISEIVRGKRAITTDTAPRLSKALGVDDRFWINIQTDYD
LEVERDLHADELAKVTTLVAS

Nucleotide

• Length: 306 bp

>AT72416 NZ_CP019400:c3570017-3569712 [Acidipropionibacterium acidipropionici]
ATGGCGACAGCATCGAAGGCACACGACCCGATCACTCCCGGCGAGATCCTGCTGACTGAGTTTCTTGAGCCGATGGGCAT
CACGCAGTACCGCCTCGCCCAGGCCACTGGACTCTCCCAGACCCGGATCAGCGAGATCGTGCGCGGCAAGCGCGCCATCA
CCACCGATACCGCCCCCCGGCTGTCCAAGGCCCTCGGGGTCGACGACCGCTTCTGGATCAACATCCAGACCGACTACGAC
CTCGAGGTCGAGCGAGACCTGCACGCCGACGAACTGGCCAAGGTGACCACCCTGGTCGCGAGCTGA