Detailed information of TA system TA072415

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2236887..2237545
• Replicon: chromosome
• Accession: NZ_CP019400
• Organism: Acidipropionibacterium acidipropionici strain WSH1105

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: K7RJ67
• Locus tag: BWX38_RS10255
• Protein ID: WP_015068846.1
• Coordinates: 2237195..2237545 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: HigA2
• Uniprot ID: -
• Locus tag: BWX38_RS10250
• Protein ID: WP_198027853.1
• Coordinates: 2236887..2237198 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWX38_RS10230	2232040..2233464	-	1425	WP_160165414.1	PKD domain-containing protein	-
BWX38_RS10235	2233592..2234848	+	1257	WP_051143434.1	IS256 family transposase	-
BWX38_RS10240	2234851..2235936	-	1086	WP_015068843.1	Tat pathway signal sequence	-
BWX38_RS10245	2236068..2236721	-	654	WP_015068844.1	hypothetical protein	-
BWX38_RS10250	2236887..2237198	-	312	WP_198027853.1	helix-turn-helix domain-containing protein	Antitoxin
BWX38_RS10255	2237195..2237545	-	351	WP_015068846.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BWX38_RS10260	2237726..2237923	+	198	WP_015068847.1	hypothetical protein	-
BWX38_RS10265	2238032..2238739	-	708	WP_015068848.1	(2Fe-2S) ferredoxin domain-containing protein	-
BWX38_RS10270	2238726..2239535	-	810	WP_015068849.1	ABC transporter ATP-binding protein	-
BWX38_RS10275	2239532..2240596	-	1065	WP_051281928.1	iron chelate uptake ABC transporter family permease subunit	-
BWX38_RS10280	2240593..2241675	-	1083	WP_148279593.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (11-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-90)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13220.22 Da
• Isoelectric Point: 10.2579

>T72415 WP_015068846.1 NZ_CP019400:c2237545-2237195 [Acidipropionibacterium acidipropionici]
MWSADLTLIADWLAGLDEGSQVQVVAAIELLKSIGPQLGRPLVDTVKASRHKNMKELRPGSSGRTELRILFAFDPRRKAI
LLIAGDKSNDWDRWYRRNIPLADDLFDEHLRALRRS

Nucleotide

• Length: 351 bp

>T72415 NZ_CP019400:c2237545-2237195 [Acidipropionibacterium acidipropionici]
ATGTGGAGCGCCGACCTCACACTCATCGCCGACTGGCTTGCCGGGCTGGACGAGGGATCACAGGTTCAGGTCGTCGCCGC
CATAGAACTGTTGAAGAGCATCGGTCCTCAACTCGGTCGCCCTCTCGTCGACACTGTCAAAGCATCACGGCACAAGAACA
TGAAGGAACTCCGACCAGGCTCATCAGGCCGAACCGAGCTGCGCATCCTGTTCGCCTTCGATCCGAGACGCAAGGCGATC
CTGCTCATCGCCGGCGACAAGAGCAATGACTGGGATCGGTGGTACCGACGCAACATCCCCCTCGCCGACGACCTGTTCGA
CGAACACCTACGAGCACTGAGAAGGTCATGA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11484.21 Da
• Isoelectric Point: 5.7484

>AT72415 WP_198027853.1 NZ_CP019400:c2237198-2236887 [Acidipropionibacterium acidipropionici]
MIMGLSLEEFLAEHPVDRDQVEAAKAEMLARVRAYRLRELREAAHLTQAQVAEKIGVSQRQVSKIETGDLNNSKLITVRK
YMEAVGGDLAVEFVSGDMRVQVA

Nucleotide

• Length: 312 bp

>AT72415 NZ_CP019400:c2237198-2236887 [Acidipropionibacterium acidipropionici]
ATGATCATGGGACTGTCCTTGGAAGAGTTTCTCGCTGAACACCCCGTGGACCGCGACCAGGTCGAGGCTGCCAAGGCCGA
GATGCTGGCTCGGGTCCGCGCCTACCGGCTCCGTGAACTGCGCGAGGCCGCCCACCTCACTCAGGCCCAGGTGGCCGAGA
AGATCGGAGTCTCCCAGCGCCAGGTTTCCAAGATCGAGACCGGCGACCTCAACAACTCCAAGCTCATCACCGTACGCAAG
TACATGGAGGCTGTCGGTGGCGACCTGGCCGTCGAGTTCGTCTCCGGTGACATGCGCGTCCAAGTGGCGTGA

Structures

Toxin

• AlphaFold DB: K7RJ67