Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 539740..540434 Replicon chromosome
Accession NZ_CP019399
Organism Pseudomonas chlororaphis strain R47

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PchlR47_RS02435 Protein ID WP_053268076.1
Coordinates 539740..540036 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A554PLA7
Locus tag PchlR47_RS02440 Protein ID WP_009046631.1
Coordinates 540033..540434 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PchlR47_RS02400 535274..535819 - 546 WP_159298913.1 hypothetical protein -
PchlR47_RS02405 535816..536070 - 255 WP_007926835.1 acyl carrier protein -
PchlR47_RS02410 536080..536340 - 261 WP_007926834.1 acyl carrier protein -
PchlR47_RS02415 536315..537130 - 816 WP_016704468.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
PchlR47_RS02420 537106..537837 - 732 WP_124301067.1 beta-ketoacyl synthase chain length factor -
PchlR47_RS02425 538171..538941 + 771 WP_007926828.1 ParA family protein -
PchlR47_RS02430 539067..539501 - 435 WP_016704469.1 thioredoxin TrxC -
PchlR47_RS02435 539740..540036 + 297 WP_053268076.1 type II toxin-antitoxin system HigB family toxin Toxin
PchlR47_RS02440 540033..540434 + 402 WP_009046631.1 transcriptional regulator Antitoxin
PchlR47_RS02445 540438..541901 - 1464 WP_124301068.1 YdiU family protein -
PchlR47_RS02450 541950..545300 - 3351 WP_009046633.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-90)

Antitoxin

Antitoxin HigA

(15-133)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11588.41 Da        Isoelectric Point: 10.6515

>T72406 WP_053268076.1 NZ_CP019399:539740-540036 [Pseudomonas chlororaphis]
MHIITAKRIWEAKSRWPQSANALETWYRKVKSLNPADFAAIKAVFPATDKVGAFHVFDIGGNKLRIIAVVRYEVRRLYIR
HVLDHHEYDKGRWKEETR

Download         Length: 297 bp

>T72406 NZ_CP019399:539740-540036 [Pseudomonas chlororaphis]
ATGCATATCATCACCGCCAAACGAATCTGGGAGGCCAAGAGCCGCTGGCCACAATCGGCCAATGCGCTGGAGACCTGGTA
CAGAAAAGTCAAAAGCCTCAATCCGGCCGATTTTGCAGCCATCAAGGCAGTATTTCCGGCCACCGACAAAGTGGGGGCGT
TCCACGTCTTCGATATTGGCGGCAACAAGTTACGAATCATCGCCGTGGTGCGTTATGAGGTGCGACGTCTCTATATCAGG
CACGTGCTGGACCATCACGAATACGACAAGGGCAGGTGGAAGGAGGAGACCAGATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14840.85 Da        Isoelectric Point: 4.4394

>AT72406 WP_009046631.1 NZ_CP019399:540033-540434 [Pseudomonas chlororaphis]
MNVLVKQAADHWHFVAPVLRKPNTEADYDALVAALDELLDLMGEDENHPVTSLVDIIGDWIEAYDEEHRPMPIASGVDVL
RSLMREHGLTQSDLPGVGAQSVVSEVLSGKRQLNLRQIRWLAERFGVSAEVFI

Download         Length: 402 bp

>AT72406 NZ_CP019399:540033-540434 [Pseudomonas chlororaphis]
ATGAACGTTCTGGTGAAGCAGGCGGCGGATCATTGGCATTTCGTGGCCCCTGTGTTGCGTAAACCCAATACTGAAGCCGA
TTACGATGCATTGGTCGCGGCGCTGGATGAACTGCTGGATCTCATGGGAGAGGACGAGAACCATCCAGTGACTTCGCTGG
TGGACATCATCGGCGATTGGATCGAAGCCTACGACGAAGAGCATCGACCGATGCCGATAGCCAGTGGTGTTGACGTCTTG
CGCTCCCTGATGCGCGAACACGGCCTGACCCAGAGTGATCTGCCAGGCGTGGGTGCGCAGTCGGTGGTTTCGGAAGTACT
GAGCGGCAAGCGCCAGCTCAACCTGCGACAGATCCGCTGGCTGGCCGAGCGCTTCGGTGTTTCGGCCGAGGTATTTATCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A554PLA7

References