Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 462517..463211 Replicon chromosome
Accession NZ_CP019397
Organism Pseudomonas sp. S19

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PspS19_RS02010 Protein ID WP_159993326.1
Coordinates 462517..462813 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PspS19_RS02015 Protein ID WP_103397313.1
Coordinates 462810..463211 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PspS19_RS01975 458196..458741 - 546 WP_159993318.1 hypothetical protein -
PspS19_RS01980 458738..458992 - 255 WP_095167185.1 acyl carrier protein -
PspS19_RS01985 459002..459262 - 261 WP_095167183.1 acyl carrier protein -
PspS19_RS01990 459243..460052 - 810 WP_159993320.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
PspS19_RS01995 460028..460747 - 720 WP_095167179.1 beta-ketoacyl synthase chain length factor -
PspS19_RS02000 461103..461873 + 771 WP_159993322.1 ParA family protein -
PspS19_RS02005 461888..462322 - 435 WP_159993324.1 thioredoxin TrxC -
PspS19_RS02010 462517..462813 + 297 WP_159993326.1 type II toxin-antitoxin system HigB family toxin Toxin
PspS19_RS02015 462810..463211 + 402 WP_103397313.1 transcriptional regulator Antitoxin
PspS19_RS02020 463218..464681 - 1464 WP_159993328.1 YdiU family protein -
PspS19_RS02025 464730..468080 - 3351 WP_159993330.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(19-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11565.41 Da        Isoelectric Point: 10.6725

>T72394 WP_159993326.1 NZ_CP019397:462517-462813 [Pseudomonas sp. S19]
MHVLTEKRVREAKVRWPMAANALDHWYQLAKGSKPSDFAAMRATFPAVDKVGELHVFDIGGNKLRLIAFVRYRSQKLYIK
HVRDHREYDRGKWKEEKA

Download         Length: 297 bp

>T72394 NZ_CP019397:462517-462813 [Pseudomonas sp. S19]
ATGCATGTTCTCACCGAAAAAAGAGTACGTGAAGCCAAGGTCAGATGGCCAATGGCAGCCAATGCGCTGGACCATTGGTA
TCAATTAGCCAAAGGAAGCAAACCGTCGGATTTTGCGGCGATGAGAGCCACATTCCCTGCTGTCGACAAGGTAGGTGAGC
TTCATGTTTTCGATATCGGTGGCAACAAGCTGCGGTTGATAGCTTTTGTCAGATATCGATCGCAAAAGCTTTATATCAAG
CATGTGCGGGATCATCGCGAATATGACCGCGGCAAGTGGAAGGAGGAAAAAGCATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 15178.37 Da        Isoelectric Point: 4.8298

>AT72394 WP_103397313.1 NZ_CP019397:462810-463211 [Pseudomonas sp. S19]
MSVLIKKAAEHWEFVSPLLRKPKSEDDYDLLAHALDELLEMTGDDESHPLMSLVDIIGDWIEEWDHKHHPMPKPSGVEIL
GYLMREHGLSQSDLPGVGPQSVVSEILSGKRQLNLRQVRWLAERFSVSVEVFI

Download         Length: 402 bp

>AT72394 NZ_CP019397:462810-463211 [Pseudomonas sp. S19]
ATGAGTGTACTGATCAAAAAAGCTGCCGAGCATTGGGAGTTTGTCTCACCGCTGCTTCGAAAACCGAAAAGTGAAGATGA
CTATGACCTGCTGGCGCATGCGCTGGACGAGTTGCTCGAGATGACGGGCGATGATGAGTCCCACCCGCTGATGAGCCTGG
TGGATATCATTGGTGACTGGATTGAGGAGTGGGACCATAAGCATCACCCGATGCCCAAGCCTAGCGGGGTCGAGATTCTT
GGCTACTTGATGCGTGAACACGGCCTCAGCCAGAGCGACCTGCCTGGCGTCGGCCCTCAGTCGGTCGTGTCCGAAATCCT
GAGTGGCAAGCGCCAGCTCAACCTGCGCCAAGTCCGCTGGTTGGCCGAGCGCTTTAGCGTGTCGGTTGAAGTCTTTATCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References