Detailed information of TA system TA072371

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3144469..3144690
• Replicon: chromosome
• Accession: NZ_CP019392
• Organism: Escherichia coli strain XH992

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A229AEQ8
• Locus tag: BW707_RS14910
• Protein ID: WP_000176713.1
• Coordinates: 3144469..3144576 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3144624..3144690 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BW707_RS14885	3140313..3141395	+	1083	WP_000804726.1	peptide chain release factor 1	-
BW707_RS14890	3141395..3142228	+	834	WP_000456446.1	peptide chain release factor N(5)-glutamine methyltransferase	-
BW707_RS14895	3142225..3142617	+	393	WP_000200374.1	invasion regulator SirB2	-
BW707_RS14900	3142621..3143430	+	810	WP_001257044.1	invasion regulator SirB1	-
BW707_RS14905	3143466..3144320	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
BW707_RS14910	3144469..3144576	-	108	WP_000176713.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	3144624..3144690	+	67	NuclAT_13	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_13	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_13	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_13	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_15	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_15	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_15	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_15	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_17	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_17	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_17	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_17	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_19	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_19	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_19	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_19	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_21	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_21	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_21	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_21	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_23	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_23	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_23	-	Antitoxin
-	3144624..3144690	+	67	NuclAT_23	-	Antitoxin
-	3144626..3144689	+	64	NuclAT_51	-	-
-	3144626..3144689	+	64	NuclAT_51	-	-
-	3144626..3144689	+	64	NuclAT_51	-	-
-	3144626..3144689	+	64	NuclAT_51	-	-
BW707_RS14915	3145004..3145111	-	108	WP_000170956.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	3145164..3145225	+	62	NuclAT_50	-	-
-	3145164..3145225	+	62	NuclAT_50	-	-
-	3145164..3145225	+	62	NuclAT_50	-	-
-	3145164..3145225	+	62	NuclAT_50	-	-
-	3145164..3145226	+	63	NuclAT_14	-	-
-	3145164..3145226	+	63	NuclAT_14	-	-
-	3145164..3145226	+	63	NuclAT_14	-	-
-	3145164..3145226	+	63	NuclAT_14	-	-
-	3145164..3145226	+	63	NuclAT_16	-	-
-	3145164..3145226	+	63	NuclAT_16	-	-
-	3145164..3145226	+	63	NuclAT_16	-	-
-	3145164..3145226	+	63	NuclAT_16	-	-
-	3145164..3145226	+	63	NuclAT_18	-	-
-	3145164..3145226	+	63	NuclAT_18	-	-
-	3145164..3145226	+	63	NuclAT_18	-	-
-	3145164..3145226	+	63	NuclAT_18	-	-
-	3145164..3145226	+	63	NuclAT_20	-	-
-	3145164..3145226	+	63	NuclAT_20	-	-
-	3145164..3145226	+	63	NuclAT_20	-	-
-	3145164..3145226	+	63	NuclAT_20	-	-
-	3145164..3145226	+	63	NuclAT_22	-	-
-	3145164..3145226	+	63	NuclAT_22	-	-
-	3145164..3145226	+	63	NuclAT_22	-	-
-	3145164..3145226	+	63	NuclAT_22	-	-
-	3145164..3145226	+	63	NuclAT_24	-	-
-	3145164..3145226	+	63	NuclAT_24	-	-
-	3145164..3145226	+	63	NuclAT_24	-	-
-	3145164..3145226	+	63	NuclAT_24	-	-
BW707_RS14920	3145517..3146617	-	1101	WP_001317783.1	sodium-potassium/proton antiporter ChaA	-
BW707_RS14925	3146887..3147117	+	231	WP_001146444.1	putative cation transport regulator ChaB	-
BW707_RS14930	3147275..3147970	+	696	WP_012311798.1	glutathione-specific gamma-glutamylcyclotransferase	-
BW707_RS14935	3148014..3148367	-	354	WP_001169669.1	DsrE/F sulfur relay family protein YchN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4031.79 Da
• Isoelectric Point: 11.4779

>T72371 WP_000176713.1 NZ_CP019392:c3144576-3144469 [Escherichia coli]
MTLTQFAMTFWHDLAAPILAGIITAAIVSWWRNRK

Nucleotide

• Length: 108 bp

>T72371 NZ_CP019392:c3144576-3144469 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT72371 NZ_CP019392:3144624-3144690 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A229AEQ8

Antitoxin