Detailed information of TA system TA072356

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 84668..85080
• Replicon: chromosome
• Accession: NZ_CP019392
• Organism: Escherichia coli strain XH992

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: BW707_RS00420
• Protein ID: WP_000132601.1
• Coordinates: 84739..85080 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	84668..84744 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BW707_RS00410	81531..83120	+	1590	WP_001063200.1	type I restriction-modification system methyltransferase	-
BW707_RS00415	83117..84511	+	1395	WP_001272445.1	type I restriction-modification system specificity subunit	-
-	84668..84744	-	77	NuclAT_8	-	Antitoxin
-	84668..84744	-	77	NuclAT_8	-	Antitoxin
-	84668..84744	-	77	NuclAT_8	-	Antitoxin
-	84668..84744	-	77	NuclAT_8	-	Antitoxin
-	84668..84744	-	77	NuclAT_9	-	Antitoxin
-	84668..84744	-	77	NuclAT_9	-	Antitoxin
-	84668..84744	-	77	NuclAT_9	-	Antitoxin
-	84668..84744	-	77	NuclAT_9	-	Antitoxin
BW707_RS00420	84739..85080	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
BW707_RS00425	85242..86621	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
BW707_RS00430	86621..87667	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T72356 WP_000132601.1 NZ_CP019392:84739-85080 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T72356 NZ_CP019392:84739-85080 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT72356 NZ_CP019392:c84744-84668 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin