Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 52628..53221 Replicon chromosome
Accession NZ_CP019388
Organism Winogradskyella sp. J14-2

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag BWZ20_RS00370 Protein ID WP_076614790.1
Coordinates 52940..53221 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BWZ20_RS00365 Protein ID WP_054560615.1
Coordinates 52628..52930 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWZ20_RS00335 47895..48443 - 549 WP_157358282.1 hypothetical protein -
BWZ20_RS00340 48593..49063 - 471 WP_076614888.1 hypothetical protein -
BWZ20_RS00345 49300..49662 - 363 WP_076614783.1 KTSC domain-containing protein -
BWZ20_RS00350 49724..50188 - 465 WP_157358283.1 hypothetical protein -
BWZ20_RS00355 50321..51064 - 744 WP_076614714.1 phytanoyl-CoA dioxygenase family protein -
BWZ20_RS00360 51218..52474 - 1257 WP_076614787.1 hypothetical protein -
BWZ20_RS00365 52628..52930 - 303 WP_054560615.1 HigA family addiction module antidote protein Antitoxin
BWZ20_RS00370 52940..53221 - 282 WP_076614790.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWZ20_RS00375 53450..54109 - 660 WP_076614791.1 hypothetical protein -
BWZ20_RS00380 54276..54725 - 450 WP_198034958.1 hypothetical protein -
BWZ20_RS00385 54933..56153 - 1221 WP_157358284.1 hypothetical protein -
BWZ20_RS00390 56286..56999 - 714 WP_076614800.1 hypothetical protein -
BWZ20_RS00395 57136..58080 - 945 WP_198034959.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(17-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-81)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11105.96 Da        Isoelectric Point: 10.6523

>T72354 WP_076614790.1 NZ_CP019388:c53221-52940 [Winogradskyella sp. J14-2]
MIISFGSKETEMIWNGIRVKKMPIEIQNVGRRKLRMLNNSQDIMDLRIPPSNRLEKLTGNLKDFYSIRINKQWRIIFKWN
NGNASEVEIIDYH

Download         Length: 282 bp

>T72354 NZ_CP019388:c53221-52940 [Winogradskyella sp. J14-2]
ATGATTATTTCATTTGGCTCGAAAGAAACCGAAATGATATGGAACGGAATTCGAGTTAAAAAAATGCCGATTGAAATTCA
GAACGTTGGACGTCGGAAATTGAGAATGTTAAACAACTCGCAAGATATTATGGACTTGAGAATTCCGCCTTCAAACCGAC
TTGAAAAACTGACTGGAAATCTAAAGGATTTTTACAGTATTCGAATTAACAAACAATGGCGAATCATTTTCAAATGGAAC
AACGGAAACGCAAGCGAAGTGGAAATAATCGACTATCATTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11625.18 Da        Isoelectric Point: 4.9663

>AT72354 WP_054560615.1 NZ_CP019388:c52930-52628 [Winogradskyella sp. J14-2]
MEKLANVHPGEVLNLEFLEPLEISAYRLSKDLKIPQTRISEIIKGRRRITADTALRLSKYFGNSAKFWLGLQDDYDIEEE
RDEKQAELDEIKQYGNKNVA

Download         Length: 303 bp

>AT72354 NZ_CP019388:c52930-52628 [Winogradskyella sp. J14-2]
ATGGAAAAGTTGGCAAATGTACATCCTGGCGAAGTCTTGAACTTGGAATTTCTTGAACCACTTGAAATCTCGGCTTACCG
ACTTTCAAAGGACTTGAAAATACCGCAAACAAGAATTTCGGAAATAATAAAAGGGAGACGCAGAATAACTGCGGACACAG
CATTAAGGTTAAGCAAGTATTTCGGAAATTCGGCCAAATTCTGGCTCGGACTTCAAGATGATTACGATATCGAAGAAGAA
CGTGATGAAAAACAGGCGGAATTGGACGAAATAAAACAATACGGAAATAAAAACGTTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References