Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1787308..1787810 Replicon chromosome
Accession NZ_CP019355
Organism Escherichia coli strain XH988

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag BWZ24_RS10405 Protein ID WP_001570036.1
Coordinates 1787556..1787810 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag BWZ24_RS10400 Protein ID WP_001259255.1
Coordinates 1787308..1787559 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWZ24_RS10375 1782486..1783553 - 1068 WP_000080087.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
BWZ24_RS10380 1783553..1784623 - 1071 WP_001297360.1 histidinol-phosphate transaminase -
BWZ24_RS10385 1784620..1785924 - 1305 WP_029402287.1 histidinol dehydrogenase -
BWZ24_RS10390 1785930..1786829 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
BWZ24_RS10395 1786975..1787025 - 51 WP_001364200.1 his operon leader peptide -
BWZ24_RS10400 1787308..1787559 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
BWZ24_RS10405 1787556..1787810 + 255 WP_001570036.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
BWZ24_RS10410 1787893..1788717 + 825 WP_000754749.1 SDR family oxidoreductase -
BWZ24_RS10415 1788763..1789692 + 930 WP_000803351.1 LysR family transcriptional regulator -
BWZ24_RS10420 1789907..1789969 + 63 WP_010723108.1 membrane protein YoeI -
BWZ24_RS10425 1789959..1791317 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
BWZ24_RS10430 1791496..1792554 + 1059 WP_000492340.1 transport protein YeeE -
BWZ24_RS10435 1792568..1792795 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10199.63 Da        Isoelectric Point: 8.0353

>T72276 WP_001570036.1 NZ_CP019355:1787556-1787810 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTLFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T72276 NZ_CP019355:1787556-1787810 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCTATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT72276 WP_001259255.1 NZ_CP019355:1787308-1787559 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT72276 NZ_CP019355:1787308-1787559 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References