72260

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5638041..5638636 Replicon chromosome
Accession NZ_CP019338
Organism Pseudomonas aeruginosa strain L10

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag BWR11_RS26725 Protein ID WP_003113526.1
Coordinates 5638358..5638636 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BWR11_RS26720 Protein ID WP_003133769.1
Coordinates 5638041..5638346 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWR11_RS26685 5633182..5634030 + 849 WP_003095007.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
BWR11_RS26695 5634197..5635138 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
BWR11_RS26700 5635255..5635869 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
BWR11_RS26705 5635911..5636495 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
BWR11_RS26710 5636536..5637636 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
BWR11_RS26720 5638041..5638346 - 306 WP_003133769.1 HigA family addiction module antidote protein Antitoxin
BWR11_RS26725 5638358..5638636 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWR11_RS26735 5638965..5641193 + 2229 WP_003141628.1 TonB-dependent receptor -
BWR11_RS26740 5641263..5641910 - 648 WP_003095021.1 carbonate dehydratase -
BWR11_RS26745 5641972..5643210 - 1239 WP_003141631.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T72260 WP_003113526.1 NZ_CP019338:c5638636-5638358 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T72260 NZ_CP019338:c5638636-5638358 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT72260 WP_003133769.1 NZ_CP019338:c5638346-5638041 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT72260 NZ_CP019338:c5638346-5638041 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References